Association of breast cancer with MRI background parenchymal enhancement: the IMAGINE case-control study
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December 9, 2020

Association of breast cancer with MRI background parenchymal enhancement: the IMAGINE case-control study

By Matsuoka
Background: Background parenchymal enhancement (BPE) on breast magnetic resonance imaging (MRI) could also be related to breast most cancers threat, however earlier research of the affiliation are equivocal and restricted by incomplete blinding of BPE evaluation. On this research, we evaluated the affiliation between BPE and breast most cancers primarily based on totally blinded assessments of BPE within the unaffected breast.
Strategies: The Imaging and Epidemiology (IMAGINE) research is a multicenter breast most cancers case-control research of girls receiving diagnostic, screening, or follow-up breast MRI, recruited from three complete most cancers facilities within the USA. Instances had a primary prognosis of unilateral breast most cancers and controls had no historical past of or present breast most cancers. A single board-certified breast radiologist with 12 years’ expertise, blinded to case-control standing and medical data, assessed the unaffected breast for BPE with out view of the affected breast of circumstances (or the corresponding breast laterality of controls). The affiliation between BPE and breast most cancers was estimated by multivariable logistic regression individually for premenopausal and postmenopausal ladies.
Outcomes: The analytic dataset included 835 circumstances and 963 controls. Adjusting for fibroglandular tissue (breast density), age, race/ethnicity, BMI, parity, household historical past of breast most cancers, BRCA1/BRCA2 mutations, and different confounders, reasonable/marked BPE (vs minimal/delicate BPE) was related to breast most cancers amongst premenopausal ladies. Amongst postmenopausal ladies, delicate/reasonable/marked vs minimal BPE had an analogous, however statistically non-significant, affiliation with breast most cancers.
Conclusions: BPE is related to breast most cancers in premenopausal ladies, and probably postmenopausal ladies, after adjustment for breast density and confounders. Our outcomes counsel that BPE needs to be evaluated alongside breast density for inclusion in fashions predicting breast most cancers threat.

Rhenium N-heterocyclic carbene complexes block development of aggressive cancers by inhibiting FGFR- and SRC-mediated signalling

Background: Platinum-based anticancer medicine have been on the frontline of most cancers remedy for the final 40 years, and are utilized in greater than half of all therapies for various most cancers sorts. Nevertheless, they aren’t universally efficient, and sufferers usually endure extreme uncomfortable side effects due to their lack of mobile selectivity. There’s subsequently a compelling want to research the anticancer exercise of other steel complexes. Right here we describe the potential anticancer exercise of rhenium-based complexes with preclinical efficacy in various kinds of stable malignancies.
Strategies: Kinase profile assay of rhenium complexes. Toxicology research utilizing zebrafish. Evaluation of the expansion of pancreatic most cancers cell line-derived xenografts generated in zebrafish and in mice upon publicity to rhenium compounds.
Outcomes: We describe rhenium complexes which block most cancers proliferation in vitro by inhibiting the signalling cascade induced by FGFR and Src. Initially, we examined the toxicity of rhenium complexes in vivo utilizing a zebrafish mannequin and recognized one compound that shows anticancer exercise with low toxicity even within the excessive micromolar vary. Notably, the rhenium complicated has anticancer exercise in very aggressive cancers corresponding to pancreatic ductal adenocarcinoma and neuroblastoma. We display the potential efficacy of this complicated through a big discount in most cancers development in mouse xenografts.
Conclusions: Our findings present a foundation for the event of rhenium-based chemotherapy brokers with enhanced selectivity and restricted uncomfortable side effects in comparison with commonplace platinum-based medicine.
Association of breast cancer with MRI background parenchymal enhancement: the IMAGINE case-control study

Association of breast cancer with MRI background parenchymal enhancement: the IMAGINE case-control study

Precision Instruments in Immuno-Oncology: Artificial Gene Circuits for Most cancers Immunotherapy

Engineered mammalian cells for medical functions have gotten a clinically related actuality because of advances in artificial biology that permit enhanced reliability and security of cell-based therapies. Nevertheless, their software continues to be hampered by challenges together with time-consuming design-and-test cycle iterations and prices. For instance, within the discipline of most cancers immunotherapy, CAR-T cells focusing on CD19 have already been clinically authorised to deal with a number of varieties of leukemia, however their use within the context of stable tumors continues to be fairly inefficient, with extra points associated to the sufficient high quality management for medical use. These limitations may be overtaken by revolutionary bioengineering approaches presently in improvement.
Right here we current an outline of latest artificial biology methods for mammalian cell therapies, with a particular concentrate on the genetic engineering enhancements on CAR-T cells, discussing situations for the subsequent era of genetic circuits for most cancers immunotherapy. Targeted ultrasound (FUS) has develop into an necessary non-invasive remedy for stable tumor ablation through thermal results. The cavitation impact induced by FUS is thereby prevented however utilized for lithotripsy, help drug supply and the induction of blood vessel destruction for most cancers remedy. On this research, head and neck most cancers (FaDu), glioblastoma (T98G), and prostate most cancers (PC-3) cells have been uncovered to FUS through the use of an in vitro FUS system adopted by single-dose X-ray radiation remedy (RT) or water tub hyperthermia (HT).

Cancer Antigen 15-3 (CA 15-3) Breast Tumor Standard Grade
GWB-4AFA2A 25000 Unit Ask for price

Cancer Antigen 15-3 (CA 15-3) Breast Tumor Standard Grade
GWB-87C810 50000 Unit Ask for price

Cancer Antigen 15-3 (CA 15-3) Breast Tumor Standard Grade
GWB-F0C8B0 25000 Unit Ask for price

Human Cancer Antigen CA15-3 Antigen Grade
GWB-C54ECC 50000 Unit Ask for price

Human Cancer Antigen CA15-3 Antigen Grade
MBS318065-50KUnits 50KUnits
EUR 2585

Human Cancer Antigen CA15-3 Antigen Grade
MBS318065-5x50KUnits 5x50KUnits
EUR 11460

Human Cancer/Testis Antigen 1B (CTAG1B) Antibody Pair Kit (with Standard)
MBS2104021-10x96Tests 10x96Tests
EUR 1480

Human Cancer/Testis Antigen 1B (CTAG1B) Antibody Pair Kit (with Standard)
MBS2104021-10x96TestsMBS2090685AbPairsSupportPack110x96Tests 10x96Tests+MBS2090685(AbPairsSupportPack1,10x96Tests)
EUR 1600

Human Cancer/Testis Antigen 1B (CTAG1B) Antibody Pair Kit (with Standard)
MBS2104021-5x96Tests 5x96Tests
EUR 935

Human Cancer/Testis Antigen 1B (CTAG1B) Antibody Pair Kit (with Standard)
MBS2104021-5x96TestsMBS2090685AbPairsSupportPack15x96Tests 5x96Tests+MBS2090685(AbPairsSupportPack1,5x96Tests)
EUR 1010

Cancer Antigen 19-9 (Gastrointestinal Cancer) Calibrator Grade
MBS319684-50KUnits 50KUnits
EUR 440

Cancer Antigen 19-9 (Gastrointestinal Cancer) Calibrator Grade
MBS319684-5x50KUnits 5x50KUnits
EUR 1800

Cancer Antigen 19-9 (Gastrointestinal Cancer) Calibrator Grade
MBS319694-50KUnits 50KUnits
EUR 515

Cancer Antigen 19-9 (Gastrointestinal Cancer) Calibrator Grade
MBS319694-5x50KUnits 5x50KUnits
EUR 2155

Gastrointestinal Cancer Antigen (CA 19-9), antigen grade
CA1991-N-10 10 KU
EUR 634.8

Cancer Antigen 125 (CA 125) Low Cross Grade
GWB-87F2DB 10000 Unit Ask for price

Cancer Antigen CA50, Calibrator Grade Protein
GWB-T00050 50KU Ask for price

Cancer Antigen 72-4 Antigen
VAng-Cr3878-10kU 10 kU
EUR 505.2
Description: Cancer Antigen 72-4 Antigen, Host/Source: Metastatic Liver. The purity is ~65% by SDS-PAGE. It is tested negative for HBsAg, antibodies to HCV and HIV 1/2.

Cancer Antigen CA242 (Gastrointestinal Cancer) Calibrator Grade Protein
GWB-T00229 50KU Ask for price

Cancer Antigen 72-4 (CA 72-4), Anti-Human; anti-Human Cancer Antigen 72-4
MBS173680-1mg 1mg
EUR 980

Cancer Antigen 72-4 (CA 72-4), Anti-Human; anti-Human Cancer Antigen 72-4
MBS173680-5x1mg 5x1mg
EUR 4210

Cancer Antigen 72-4 (CA 72-4), Anti-Human; anti-Human Cancer Antigen 72-4
MBS173681-1mg 1mg
EUR 980

Cancer Antigen 72-4 (CA 72-4), Anti-Human; anti-Human Cancer Antigen 72-4
MBS173681-5x1mg 5x1mg
EUR 4205

Cancer Antigen 27-29 (CA 27-29) Low Cross Grade
GWB-16367E 10000 Unit Ask for price

Cancer Antigen 15-3 (CA 15-3) Low Cross Grade
GWB-E47BC0 10000 Unit Ask for price

CA125 Cancer Antigen (Ovarian Cancer), Low Cross Reactivity, Calibrator Grade
MBS651672-50KUnits 50KUnits
EUR 710

CA125 Cancer Antigen (Ovarian Cancer), Low Cross Reactivity, Calibrator Grade
MBS651672-5x50KUnits 5x50KUnits
EUR 3055

OPMA04167-50KIU - Human Cancer Antigen CA15-3 Antigen Grade Protein
OPMA04167-50KIU 50KU
EUR 2999

Cancer Antigen 72-4 (CA 72-4), Human
MBS173393-1000Units 1000Units
EUR 200

Cancer Antigen 72-4 (CA 72-4), Human
MBS173393-5000Units 5000Units
EUR 350

Cancer Antigen 72-4 (CA 72-4), Human
MBS173393-50KUnits 50KUnits
EUR 1800

Cancer Antigen 72-4 (CA 72-4), Human
MBS173393-5x50KUnits 5x50KUnits
EUR 7880

Cancer Antigen 125 (CA 125) High Purity Low Cross Grade
GWB-12E060 20000 Unit Ask for price

Cancer Antigen 125 (CA 125) Cell Culture Low Cross Grade
GWB-143910 25000 Unit Ask for price

BSA (Standard Grade)
30-AB70 1 kg
EUR 875
Description: Standard Grade Bovine Serum Albumin (99% pure)

BSA (Standard Grade)
MBS537004-1kg 1kg
EUR 1360

BSA (Standard Grade)
MBS537004-5x1kg 5x1kg
EUR 6025

Cancer Antigen 19-9 (CA 19-9) High Purity Iodination Grade
GWB-453206 50000 Unit Ask for price

Cancer Antigen 72-4 (CA 72-4) High Purity
GWB-51B0D9 50000 Unit Ask for price

Cancer Antigen 15-3 (CA 15-3) Cell Culture Low Cross Grade
GWB-553B7B 10000 Unit Ask for price

CA15-3, standard grade
MBS664086-1Unit 1Unit
EUR 1605

CA15-3, standard grade
MBS664086-5x1Unit 5x1Unit
EUR 6885

Cancer Antigen 72-4 (CA72-4) Antibody
MBS569465-1mg 1mg
EUR 450

Cancer Antigen 72-4 (CA72-4) Antibody
MBS569465-5x1mg 5x1mg
EUR 1820

Cancer Antigen 72-4 (CA72-4) Antibody
MBS569466-1mg 1mg
EUR 450

Cancer Antigen 72-4 (CA72-4) Antibody
MBS569466-5x1mg 5x1mg
EUR 1820

Cancer antigen 72-4(CA72-4) antibody
NBP2058 each
EUR 368
Description: LF EIA,CLIA

Cancer antigen 72-4(CA72-4) antibody
NBP2059 each
EUR 368
Description: LF EIA,CLIA

Human Cancer Antigen 72-4,CA 72-4 ELISA KIT
E4598Hu-1096T 10*96T
EUR 4122

Human Cancer Antigen 72-4,CA 72-4 ELISA KIT
E4598Hu-48wells 48 wells
EUR 300

Human Cancer Antigen 72-4,CA 72-4 ELISA KIT
E4598Hu-596T 5*96T
EUR 2061

Human Cancer Antigen 72-4,CA 72-4 ELISA KIT
E4598Hu-96wells 96 wells
EUR 458

Human Cancer Antigen 72-4,CA 72-4 ELISA KIT
JOT-EK4598Hu 96 wells Ask for price
Description: Human

Human Cancer Antigen 72-4 (CA 72-4) ELISA Kit
MBS167911-10x96StripWells 10x96-Strip-Wells
EUR 3460

Human Cancer Antigen 72-4 (CA 72-4) ELISA Kit
MBS167911-48StripWells 48-Strip-Wells
EUR 285

Human Cancer Antigen 72-4 (CA 72-4) ELISA Kit
MBS167911-5x96StripWells 5x96-Strip-Wells
EUR 1750

Human Cancer Antigen 72-4 (CA 72-4) ELISA Kit
MBS167911-96StripWells 96-Strip-Wells
EUR 425

Human Cancer Antigen 72-4, CA 72-4 GENLISA ELISA
KBH4598 1 x 96 wells
EUR 286

Human Ovarian Cancer Immuno Reactive Antigen Domain Containing Protein 2 (OCIAD2) Antibody Pair Kit (with Standard)
MBS2104606-10x96Tests 10x96Tests
EUR 1615

Human Ovarian Cancer Immuno Reactive Antigen Domain Containing Protein 2 (OCIAD2) Antibody Pair Kit (with Standard)
MBS2104606-10x96TestsMBS2090685AbPairsSupportPack110x96Tests 10x96Tests+MBS2090685(AbPairsSupportPack1,10x96Tests)
EUR 1735

Human Ovarian Cancer Immuno Reactive Antigen Domain Containing Protein 2 (OCIAD2) Antibody Pair Kit (with Standard)
MBS2104606-5x96Tests 5x96Tests
EUR 1020

Human Ovarian Cancer Immuno Reactive Antigen Domain Containing Protein 2 (OCIAD2) Antibody Pair Kit (with Standard)
MBS2104606-5x96TestsMBS2090685AbPairsSupportPack15x96Tests 5x96Tests+MBS2090685(AbPairsSupportPack1,5x96Tests)
EUR 1090

Tryptase Human Standard Grade
GWB-4CE407 0.1 mg Ask for price

OPEF01577-10KU - Cancer Antigen 72-4 (CA72-4) Antigen
OPEF01577-10KU 10kU
EUR 185

Transferrin Receptor Standard Grade
GWB-CDE6A4 1 mg Ask for price

Florisil@ -200 Mesh Standard Grade
F01454 100G
EUR 197.04
Description: CAS N° 1343-88-0

Standard grade - 961, Dia/Size in cm12.5
9610-1250-50C 1 unit
EUR 14.2
Description: Standard grade - 961, Dia/Size in cm12.5

Standard grade - 610, Dia/Size in cm12.5
6100-1250-100C 1 unit
EUR 20.85
Description: Standard grade - 610, Dia/Size in cm12.5

Standard grade - 961, Dia/Size in 46x57
9610-4657-100S 1 unit
EUR 424.61
Description: Standard grade - 961, Dia/Size in 46x57

Standard grade - 961, Dia/Size in cm 9
9610-0900-100C 1 unit
EUR 22.26
Description: Standard grade - 961, Dia/Size in cm 9

Standard grade - 961, Dia/Size in cm 11
9610-1100-100C 1 unit
EUR 26.7
Description: Standard grade - 961, Dia/Size in cm 11

Standard grade - 961, Dia/Size in cm 12.
9610-1250-100C 1 unit
EUR 32.68
Description: Standard grade - 961, Dia/Size in cm 12.

Standard grade - 961, Dia/Size in cm 15
9610-1500-100C 1 unit
EUR 44.54
Description: Standard grade - 961, Dia/Size in cm 15

Standard grade - 610, Dia/Size in cm 15
6100-1500-100C 1 unit
EUR 32.68
Description: Standard grade - 610, Dia/Size in cm 15

Standard grade - 613, Dia/Size in cm 4.7
6130-0470-100C 1 unit
EUR 7.89
Description: Standard grade - 613, Dia/Size in cm 4.7

Standard grade - 613, Dia/Size in cm 7.5
6130-0750-100C 1 unit
EUR 8.69
Description: Standard grade - 613, Dia/Size in cm 7.5

Standard grade - 613, Dia/Size in cm 11
6130-1100-100C 1 unit
EUR 11.53
Description: Standard grade - 613, Dia/Size in cm 11

Standard grade - 613, Dia/Size in cm 50
6130-5050-100S 1 unit
EUR 169.94
Description: Standard grade - 613, Dia/Size in cm 50

Standard grade - 615, Dia/Size in cm 12.
6150-1250-100C 1 unit
EUR 18.27
Description: Standard grade - 615, Dia/Size in cm 12.

Standard grade - 615, Dia/Size in cm 18.
6150-1850-100C 1 unit
EUR 33.29
Description: Standard grade - 615, Dia/Size in cm 18.

Standard grade - 615, Dia/Size in cm 46
6150-4657-100S 1 unit
EUR 197.98
Description: Standard grade - 615, Dia/Size in cm 46

Standard Grade -631 , Dia/size in cm 7
6310-0700-100C 1 unit
EUR 10.42
Description: Standard Grade -631 , Dia/size in cm 7

Standard Grade -631 , Dia/size in cm 9
6310-0900-100C 1 unit
EUR 11.84
Description: Standard Grade -631 , Dia/size in cm 9

Standard grade - 631, Dia/Size in cm 12.
6310-1250-100C 1 unit
EUR 17.84
Description: Standard grade - 631, Dia/Size in cm 12.

Standard Grade =642 , Dia/size in 7 cm
6420-0700-100C 1 unit
EUR 13.41
Description: Standard Grade =642 , Dia/size in 7 cm

Standard Grade =642 , Dia/size in 9 cm
6420-0900-100C 1 unit
EUR 13.41
Description: Standard Grade =642 , Dia/size in 9 cm

Standard Grade =642 , Dia/size in 11 cm
6420-1100-100C 1 unit
EUR 14.86
Description: Standard Grade =642 , Dia/size in 11 cm

Standard grade - 642, Dia/Size in cm 12.
6420-1250-100C 1 unit
EUR 16.27
Description: Standard grade - 642, Dia/Size in cm 12.

Standard grade - 642, Dia/Size in cm 46
6428-4657-100S 1 unit
EUR 954.89
Description: Standard grade - 642, Dia/Size in cm 46

Standard grade - 601, Dia/Size in cm 11
6010-1100-100C 1 unit
EUR 11.84
Description: Standard grade - 601, Dia/Size in cm 11

Standard grade - 601, Dia/Size in cm 12.
6010-1250-100C 1 unit
EUR 12.79
Description: Standard grade - 601, Dia/Size in cm 12.

Standard grade - 601, Dia/Size in cm 15
6010-1500-100C 1 unit
EUR 16.27
Description: Standard grade - 601, Dia/Size in cm 15

Standard grade - 601, Dia/Size in cm 46
6018-4657-100S 1 unit
EUR 197.06
Description: Standard grade - 601, Dia/Size in cm 46

Standard grade - 131, Dia/Size in cm 4.7
1310-0470-100C 1 unit
EUR 82.59
Description: Standard grade - 131, Dia/Size in cm 4.7

Standard grade - 161, Dia/Size in cm 4.7
1610-0470-100C 1 unit
EUR 88.63
Description: Standard grade - 161, Dia/Size in cm 4.7

Proteinase K, Recombinant, Standard Grade
9250-100 each
EUR 124.8

Proteinase K, Recombinant, Standard Grade
9250-10G each
EUR 4627.2

Proteinase K, Recombinant, Standard Grade
9250-1G each
EUR 548.4

Proteinase K, Recombinant, Standard Grade
9250-500 each
EUR 314.4

Proteinase K, Recombinant, Standard Grade
9251-100 each
EUR 1266

Proteinase K, Recombinant, Standard Grade
9251-25 each
EUR 352.8

Proteinase K, Recombinant, Standard Grade
9251-5 each
EUR 144

Standard Grade-610, Dia/size in 7 cm
6100-0700-100C 1 unit
EUR 13.41
Description: Standard Grade-610, Dia/size in 7 cm

Standard grade native Human HE4 protein
MBS5308336-1000pM 1000pM
EUR 370

Standard grade native Human HE4 protein
MBS5308336-5x1000pM 5x1000pM
EUR 1520

Standard grade - 613, Dia/Size in cm 7 R
6130-0700-100C 1 unit
EUR 8.69
Description: Standard grade - 613, Dia/Size in cm 7 R

Standard grade - 613, Dia/Size in cm 9 R
6130-0900-100C 1 unit
EUR 9.79
Description: Standard grade - 613, Dia/Size in cm 9 R

Standard grade - 601, Dia/Size in cm 7 R
6010-0700-100C 1 unit
EUR 15.8
Description: Standard grade - 601, Dia/Size in cm 7 R

Standard grade - 601, Dia/Size in cm 9 R
6010-0900-100C 1 unit
EUR 10.42
Description: Standard grade - 601, Dia/Size in cm 9 R

OAEF00718-1MG - Cancer Antigen 72-4 (CA72-4) Antibody
OAEF00718-1MG 1mg
EUR 399

OAEF00719-1MG - Cancer Antigen 72-4 (CA72-4) Antibody
OAEF00719-1MG 1mg
EUR 399

Standard grade - 54, Dia/Size in cm 12.5
0540-1250-100C 1 unit
EUR 44.54
Description: Standard grade - 54, Dia/Size in cm 12.5

Standard grade - 54, Dia/Size in cm 18.5
0540-1850-100C 1 unit
EUR 101.67
Description: Standard grade - 54, Dia/Size in cm 18.5

Standard grade - 55, Dia/Size in cm 11
0550-1100-100C 1 unit
EUR 38.04
Description: Standard grade - 55, Dia/Size in cm 11

Standard grade - 55, Dia/Size in cm 12.5
0550-1250-100C 1 unit
EUR 48.17
Description: Standard grade - 55, Dia/Size in cm 12.5

Standard grade - 74, Dia/Size in cm 12.5
0740-1250-100C 1 unit
EUR 41.54
Description: Standard grade - 74, Dia/Size in cm 12.5

Standard grade - 94, Dia/Size in cm 7
0940-0700-100C 1 unit
EUR 22.26
Description: Standard grade - 94, Dia/Size in cm 7

Standard grade - 94, Dia/Size in cm 12.5
0940-1250-100C 1 unit
EUR 41.54
Description: Standard grade - 94, Dia/Size in cm 12.5

Filamin Standard Grade From Chicken Gizzard
GWB-955E5F 0.25 mg Ask for price

Standard grade - 54, Dia/Size in cm 46x5
0540-4657-100S 1 unit
EUR 525.21
Description: Standard grade - 54, Dia/Size in cm 46x5

Standard grade - 55, Dia/Size in cm 46x5
0550-4657-100S 1 unit
EUR 819.06
Description: Standard grade - 55, Dia/Size in cm 46x5

Standard grade - 74, Dia/Size in cm 46x5
0740-4657-100S 1 unit
EUR 556.3
Description: Standard grade - 74, Dia/Size in cm 46x5

Standard grade - 94, Dia/Size in cm 46x5
0940-4657-100S 1 unit
EUR 531.04
Description: Standard grade - 94, Dia/Size in cm 46x5

Bovine Serum Albumin, Standard Grade, pH 7.0
A0210-010 100g
EUR 170

Bovine Serum Albumin, Standard Grade, pH 7.0
A0210-050 500g
EUR 720

Bovine Serum Albumin, Standard Grade, pH 7.0
A0210-100 1Kg
EUR 890

Bovine Serum Albumin, Standard Grade, pH 7.0
A0210-110 10Kg
EUR 8100

Bovine Serum Albumin Standard Grade pH 7.0
GWB-555343 1 kg Ask for price

Bovine Serum Albumin Standard Grade pH 5.2
GWB-AA0E82 1 kg Ask for price

Human Cancer Antigen CA72-4 (TAG-72) Protein
abx061471-100g 100 µg Ask for price

Human Cancer Antigen CA72-4 (TAG-72) Protein
abx061471-10g 10 µg
EUR 1500

Human Cancer Antigen CA72-4 (TAG-72) Protein
abx061471-50g 50 µg Ask for price
Sensitization results of quick FUS pictures with cavitation (FUS-Cav) or with out cavitation (FUS) to RT or HT have been evaluated. FUS-Cav considerably will increase the sensitivity of most cancers cells to RT and HT by lowering long-term clonogenic survival, short-term cell metabolic exercise, cell invasion, and induction of sonoporation. Our outcomes demonstrated that quick FUS remedy with cavitation has good potential to sensitize most cancers cells to RT and HT non-invasively.
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