Epitranscriptomic regulation by m 6 A RNA methylation in mind growth and ailments
- Mobile RNAs are pervasively tagged with numerous chemical moieties, collectively known as epitranscriptomic modifications. The methylation of adenosine at N6place generates N6-methyladenosine (m6A), which is essentially the most ample and reversible epitranscriptomic modification in mammals.
- The m6A signaling is mediated by a devoted set of proteins comprised of writers, erasers, and readers. Opposite to the activation-repression binary view of gene regulation, rising proof means that the m6A methylation controls a number of elements of mRNA metabolism, akin to splicing, export, stability, translation, and degradation, culminating within the fine-tuning of gene expression.
- Mind exhibits the best abundance of m6A methylation within the physique, which is developmentally altered. Inside the mind, m6A methylation is biased towards neuronal transcripts and delicate to neuronal exercise. In a wholesome mind, m6A maintains a number of developmental and physiological processes akin to neurogenesis, axonal development, synaptic plasticity, circadian rhythm, cognitive perform, and stress response. The m6A imbalance contributes to the pathogenesis of acute and continual CNS insults, mind most cancers, and neuropsychiatric problems.
- This overview mentioned the molecular mechanisms of m6A regulation and its implication within the developmental, physiological, and pathological processes of the mind.
influenza-x
 Antibody) GNAS Complex Locus (GNAS) Antibody |
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20-abx214029 |
Abbexa |
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GNAS Complex Locus (GNAS) Antibody |
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20-abx214658 |
Abbexa |
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 GNAS Antibody |
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1-CSB-PA307619LA01HU |
Cusabio |
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Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:200-1:500 |
GNAS Antibody |
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1-CSB-PA352389LA01HU |
Cusabio |
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Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
GNAS Antibody |
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1-CSB-PA247539 |
Cusabio |
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Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:5000, WB:1:200-1:1000, IHC:1:25-1:100 |
GNAS Antibody |
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1-CSB-PA009596GA01HU |
Cusabio |
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Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
GNAS Antibody |
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1-CSB-PA147947 |
Cusabio |
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Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
GNAS Antibody |
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32899-100ul |
SAB |
100ul |
EUR 252 |
 GNAS antibody |
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38452-100ul |
SAB |
100ul |
EUR 252 |
GNAS Antibody |
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DF7068 |
Affbiotech |
200ul |
EUR 304 |
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Description: GNAS Antibody detects endogenous levels of total GNAS. |
GNAS Antibody |
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DF7388 |
Affbiotech |
200ul |
EUR 304 |
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Description: GNAS Antibody detects endogenous levels of total GNAS. |
GNAS antibody |
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70R-1643 |
Fitzgerald |
100 ug |
EUR 377 |
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Description: Rabbit polyclonal GNAS antibody raised against the N terminal of GNAS |
GNAS antibody |
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70R-1651 |
Fitzgerald |
100 ug |
EUR 377 |
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Description: Rabbit polyclonal GNAS antibody raised against the C terminal of GNAS |
GNAS antibody |
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70R-1652 |
Fitzgerald |
100 ug |
EUR 377 |
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Description: Rabbit polyclonal GNAS antibody raised against the N terminal of GNAS |
GNAS antibody |
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70R-21619 |
Fitzgerald |
50 ul |
EUR 435 |
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Description: Rabbit polyclonal GNAS antibody |
GNAS antibody |
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70R-12940 |
Fitzgerald |
100 ul |
EUR 457 |
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Description: Affinity purified Rabbit polyclonal GNAS antibody |
GNAS antibody |
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70R-13520 |
Fitzgerald |
100 ul |
EUR 457 |
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Description: Affinity purified Rabbit polyclonal GNAS antibody |
GNAS antibody |
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70R-5756 |
Fitzgerald |
50 ug |
EUR 467 |
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Description: Rabbit polyclonal GNAS antibody raised against the N terminal of GNAS |
 Antibody (HRP)) GNAS Complex Locus (GNAS) Antibody (HRP) |
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20-abx337231 |
Abbexa |
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EUR 411.00
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EUR 1845.00
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EUR 599.00
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EUR 182.00
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EUR 300.00
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- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
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 Antibody (FITC)) GNAS Complex Locus (GNAS) Antibody (FITC) |
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20-abx337232 |
Abbexa |
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EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
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 Antibody (Biotin)) GNAS Complex Locus (GNAS) Antibody (Biotin) |
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20-abx337233 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
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|
 polyclonal antibody) GNAS complex locus (GNAS) polyclonal antibody |
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ABP-PAB-11314 |
Allele Biotech |
100 ug |
Ask for price |
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 Anti-GNAS antibody |
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STJ27492 |
St John's Laboratory |
100 µl |
EUR 277 |
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Description: This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. |
Anti-GNAS antibody |
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STJ23816 |
St John's Laboratory |
100 µl |
EUR 277 |
|
Description: This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. |
) GNAS Antibody (HRP) |
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20-abx306647 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
) GNAS Antibody (FITC) |
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20-abx306648 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
) GNAS Antibody (Biotin) |
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20-abx306649 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
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|
 GNAS Polyclonal Antibody |
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A64422 |
EpiGentek |
100 µg |
EUR 570.55 |
|
Description: The best epigenetics products |
GNAS Polyclonal Antibody |
|
A68803 |
EpiGentek |
100 ?g |
EUR 628.55 |
|
Description: Ask the seller for details |
 NESP55,GNAS Antibody |
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abx235663-100ug |
Abbexa |
100 ug |
EUR 481 |
|
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 anti- GNAS antibody |
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FNab03536 |
FN Test |
100µg |
EUR 505.25 |
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Description: Antibody raised against GNAS |
 GNAS Conjugated Antibody |
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C32899 |
SAB |
100ul |
EUR 397 |
 GNAS siRNA |
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20-abx918154 |
Abbexa |
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GNAS siRNA |
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20-abx918155 |
Abbexa |
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GNAS siRNA |
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20-abx918156 |
Abbexa |
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GNAS siRNA |
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20-abx918157 |
Abbexa |
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GNAS siRNA |
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20-abx918158 |
Abbexa |
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GNAS siRNA |
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20-abx918159 |
Abbexa |
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GNAS siRNA |
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20-abx918160 |
Abbexa |
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GNAS siRNA |
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20-abx918161 |
Abbexa |
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GNAS siRNA |
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20-abx900009 |
Abbexa |
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GNAS siRNA |
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20-abx900030 |
Abbexa |
|
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 GNAS Peptide |
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42-594P |
ProSci |
0.1 mg |
EUR 338 |
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Description: (IN) GNAS Peptide |
 GNAS Antibody, HRP conjugated |
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1-CSB-PA307619LB01HU |
Cusabio |
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Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
 GNAS Antibody, FITC conjugated |
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1-CSB-PA307619LC01HU |
Cusabio |
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Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
 GNAS Antibody, Biotin conjugated |
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1-CSB-PA307619LD01HU |
Cusabio |
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Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
GNAS Antibody, HRP conjugated |
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1-CSB-PA352389LB01HU |
Cusabio |
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|
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Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
GNAS Antibody, FITC conjugated |
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1-CSB-PA352389LC01HU |
Cusabio |
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|
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Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
GNAS Antibody, Biotin conjugated |
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1-CSB-PA352389LD01HU |
Cusabio |
|
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|
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Description: A polyclonal antibody against GNAS. Recognizes GNAS from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
) Polyclonal GNAS Antibody (Center) |
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APR05815G |
Leading Biology |
0.1ml |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GNAS (Center). This antibody is tested and proven to work in the following applications: |
 anti- NESP55,GNAS antibody |
|
FNab05663 |
FN Test |
100µg |
EUR 505.25 |
|
|
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Description: Antibody raised against NESP55,GNAS |
 Monoclonal GNAS Antibody, Clone: 7G6G5 |
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AMM03034G |
Leading Biology |
0.1ml |
EUR 528 |
|
Description: A Monoclonal antibody against Human GNAS. The antibodies are raised in Mouse and are from clone 7G6G5. This antibody is applicable in WB and IHC, FC, ICC, E |
 Monoclonal GNAS Antibody, Clone: 2A2B7 |
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AMM03035G |
Leading Biology |
0.1ml |
EUR 528 |
|
Description: A Monoclonal antibody against Human GNAS. The antibodies are raised in Mouse and are from clone 2A2B7. This antibody is applicable in WB and IHC, FC, ICC, E |
) Polyclonal GNAS Antibody (N-Term) |
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AMM04827G |
Leading Biology |
0.1ml |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GNAS (N-Term). This antibody is tested and proven to work in the following applications: |
) Polyclonal GNAS Antibody (internal region) |
|
APG00677G |
Leading Biology |
0.1mg |
EUR 484 |
|
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human GNAS (internal region). This antibody is tested and proven to work in the following applications: |
) Polyclonal GNAS Antibody (aa385-394) |
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APR02185G |
Leading Biology |
0.05mg |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GNAS (aa385-394). This antibody is tested and proven to work in the following applications: |
) Polyclonal GNAS Antibody (C-term) |
|
APR04328G |
Leading Biology |
0.1ml |
EUR 484 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GNAS (C-term). This antibody is tested and proven to work in the following applications: |
 GNAS Polyclonal Antibody, HRP Conjugated |
|
A64423 |
EpiGentek |
100 µg |
EUR 570.55 |
|
Description: kits suitable for this type of research |
 GNAS Polyclonal Antibody, FITC Conjugated |
|
A64424 |
EpiGentek |
100 µg |
EUR 570.55 |
|
Description: fast delivery possible |
 GNAS Polyclonal Antibody, Biotin Conjugated |
|
A64425 |
EpiGentek |
100 µg |
EUR 570.55 |
|
Description: reagents widely cited |
GNAS Polyclonal Antibody, HRP Conjugated |
|
A68804 |
EpiGentek |
100 ?g |
EUR 628.55 |
|
Description: The best epigenetics products |
GNAS Polyclonal Antibody, FITC Conjugated |
|
A68805 |
EpiGentek |
100 ?g |
EUR 628.55 |
|
Description: kits suitable for this type of research |
GNAS Polyclonal Antibody, Biotin Conjugated |
|
A68806 |
EpiGentek |
100 ?g |
EUR 628.55 |
|
Description: fast delivery possible |
 GNAS cloning plasmid |
|
CSB-CL009596HU1-10ug |
Cusabio |
10ug |
EUR 233 |
|
|
|
Description: A cloning plasmid for the GNAS gene. |
GNAS cloning plasmid |
|
CSB-CL009596HU2-10ug |
Cusabio |
10ug |
EUR 233 |
|
|
|
Description: A cloning plasmid for the GNAS gene. |
 GNAS Rabbit pAb |
|
A5546-100ul |
Abclonal |
100 ul |
EUR 308 |
GNAS Rabbit pAb |
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A5546-200ul |
Abclonal |
200 ul |
EUR 459 |
GNAS Rabbit pAb |
|
A5546-20ul |
Abclonal |
20 ul |
EUR 183 |
GNAS Rabbit pAb |
|
A5546-50ul |
Abclonal |
50 ul |
EUR 223 |
GNAS Rabbit pAb |
|
A2732-100ul |
Abclonal |
100 ul |
EUR 308 |
GNAS Rabbit pAb |
|
A2732-200ul |
Abclonal |
200 ul |
EUR 459 |
GNAS Rabbit pAb |
|
A2732-20ul |
Abclonal |
20 ul |
EUR 183 |
GNAS Rabbit pAb |
|
A2732-50ul |
Abclonal |
50 ul |
EUR 223 |
 Recombinant human GNAS |
|
P1012 |
FN Test |
100ug |
Ask for price |
|
|
|
Description: Recombinant protein for human GNAS |
 GNAS Blocking Peptide |
|
DF7068-BP |
Affbiotech |
1mg |
EUR 195 |
GNAS Blocking Peptide |
|
DF7388-BP |
Affbiotech |
1mg |
EUR 195 |
GNAS Blocking Peptide |
|
33R-6814 |
Fitzgerald |
100 ug |
EUR 180 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GNAS antibody, catalog no. 70R-1643 |
GNAS Blocking Peptide |
|
33R-8471 |
Fitzgerald |
100 ug |
EUR 180 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GNAS antibody, catalog no. 70R-1652 |
GNAS Blocking Peptide |
|
33R-10097 |
Fitzgerald |
100 ug |
EUR 180 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GNAS antibody, catalog no. 70R-1651 |
GNAS Blocking Peptide |
|
33R-9925 |
Fitzgerald |
100 ug |
EUR 180 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GNAS antibody, catalog no. 70R-5756 |
 Mouse GNAS shRNA Plasmid |
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20-abx970580 |
Abbexa |
|
|
|
|
Mouse GNAS shRNA Plasmid |
|
20-abx970581 |
Abbexa |
|
|
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|
Mouse GNAS shRNA Plasmid |
|
20-abx970583 |
Abbexa |
|
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|
Mouse GNAS shRNA Plasmid |
|
20-abx970582 |
Abbexa |
|
|
|
|
 Rat GNAS shRNA Plasmid |
|
20-abx984695 |
Abbexa |
|
|
|
|
Rat GNAS shRNA Plasmid |
|
20-abx984696 |
Abbexa |
|
|
|
|
 Human GNAS shRNA Plasmid |
|
20-abx951847 |
Abbexa |
|
|
|
|
Human GNAS shRNA Plasmid |
|
20-abx951848 |
Abbexa |
|
|
|
|
RNA-Binding Proteins in Most cancers: Practical and Therapeutic Views
RNA-binding proteins (RBPs) crucially regulate gene expression by post-transcriptional regulation, akin to by modulating microRNA (miRNA) processing and the choice splicing, different polyadenylation, subcellular localization, stability, and translation of RNAs. Greater than 1500 RBPs have been recognized so far, and plenty of of them are recognized to be deregulated in most cancers. Alterations within the expression and localization of RBPs can affect the expression ranges of oncogenes, tumor-suppressor genes, and genome stability-related genes.
RBP-mediated gene regulation can result in numerous cancer-related mobile phenotypes, akin to proliferation, apoptosis, angiogenesis, senescence, and epithelial-mesenchymal transition (EMT)/invasion/metastasis. This regulation can be related to most cancers prognosis.
Thus, RBPs could be potential targets for the event of therapeutics for the most cancers therapy. On this overview, we describe the molecular features of RBPs, their roles in cancer-related mobile phenotypes, and numerous approaches that could be used to focus on RBPs for most cancers therapy.
Circulating Lengthy Non-Coding RNA GAS5 Is Overexpressed in Serum from Osteoporotic Sufferers and Is Related to Elevated Danger of Bone Fragility
Osteoporosis (OP) is a multifactorial dysfunction through which environmental elements together with genetic variants and epigenetic mechanisms have been implicated. Lengthy non-coding RNAs (lncRNAs) have just lately emerged as essential regulators of bone metabolism and OP aetiology.
On this research, we analyzed the expression degree and the genetic affiliation of lncRNA GAS5 in OP sufferers in comparison with controls. Quantitative RT-PCR evaluation of GAS5 was carried out on the serum of 56 OP sufferers and 28 wholesome people. OP topics had been divided into three teams of research: 29 with fragility fractures of lumbar backbone (OP_VF), 14 with fragility fractures of femoral neck (OP_FF) and 13 with out fractures (OP_WF). Genotyping of the rs145204276 insertion/deletion polymorphism has additionally been carried out by Restriction fragment size polymorphism (RFLP) and direct sequencing analyses.
Expression of circulating GAS5 is considerably elevated in OP sufferers in comparison with controls (p < 0.01), with a statistically greater significance in fractured OP people vs. wholesome topics (p < 0.001). No statistically important change was present in feminine OP sufferers; conversely, GAS5 is upregulated within the subgroup of fractured OP ladies sera (p < 0.01) and in all OP males (p < 0.05). Moreover, a direct correlation between GAS5 expression degree and parathyroid hormone (PTH) focus was present in OP sufferers (r = 0.2930; p = 0.0389).
Genetic evaluation of rs145204276 revealed that the deletion allele was correlated with the next expression of GAS5 in OP sufferers (0.22 ± 0.02 vs. 0.15 ± 0.01, ** p < 0.01). Our outcomes recommend circulating GAS5 as a putative biomarker for the prognosis and prognosis of OP and OP-related fractures.
 SOX2 Antibody |
|
CSB-PA982860- |
Cusabio |
|
EUR 335 |
|
|
|
Description: A polyclonal antibody against SOX2. Recognizes SOX2 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000 |
SOX2 Antibody |
|
CSB-PA982860-100ul |
Cusabio |
100ul |
EUR 316 |
|
|
|
Description: A polyclonal antibody against SOX2. Recognizes SOX2 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000 |
SOX2 Antibody |
|
1-CSB-PA698932 |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against SOX2. Recognizes SOX2 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:25-1:100 |
SOX2 Antibody |
|
1-CSB-PA022426GA01HU |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against SOX2. Recognizes SOX2 from Human, Mouse, Rat, Zebrafish. This antibody is Unconjugated. Tested in the following application: ELISA, IF |
SOX2 Antibody |
|
1-CSB-PA16539A0Rb |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against SOX2. Recognizes SOX2 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
SOX2 Antibody |
|
1-CSB-PA588368 |
Cusabio |
|
|
|
|
|
Description: A polyclonal antibody against SOX2. Recognizes SOX2 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:15-1:50 |
SOX2 Antibody |
|
21425-100ul |
SAB |
100ul |
EUR 252 |
SOX2 Antibody |
|
21425-50ul |
SAB |
50ul |
EUR 187 |
SOX2 Antibody |
|
25044-100ul |
SAB |
100ul |
EUR 390 |
SOX2 Antibody |
|
31128-100ul |
SAB |
100ul |
EUR 252 |
SOX2 Antibody |
|
31128-50ul |
SAB |
50ul |
EUR 187 |
 SOX2 antibody |
|
38134-100ul |
SAB |
100ul |
EUR 252 |
SOX2 Antibody |
|
43142-100ul |
SAB |
100ul |
EUR 252 |
SOX2 Antibody |
|
48128-100ul |
SAB |
100ul |
EUR 333 |
SOX2 Antibody |
|
48128-50ul |
SAB |
50ul |
EUR 239 |
SOX2 Antibody |
|
DF6109 |
Affbiotech |
200ul |
EUR 304 |
|
Description: SOX2 Antibody detects endogenous levels of total SOX2. |
 sox2 Antibody |
|
AF7950 |
Affbiotech |
200ul |
EUR 376 |
|
Description: sox2 Antibody detects endogenous levels of sox2. |
SOX2 Antibody |
|
BF0481 |
Affbiotech |
200ul |
EUR 376 |
|
Description: SOX2 antibody detects endogenous levels of total SOX2. |
SOX2 Antibody |
|
AF4010 |
Affbiotech |
200ul |
EUR 376 |
|
Description: The antibody detects endogenous level of total SOX2 protein. |
SOX2 Antibody |
|
AF5140 |
Affbiotech |
200ul |
EUR 304 |
|
Description: SOX2 Antibody detects endogenous levels of total SOX2. |
 Sox2 antibody |
|
20R-1751 |
Fitzgerald |
100 ug |
EUR 673 |
|
Description: Rabbit polyclonal Sox2 antibody |
SOX2 antibody |
|
20R-2500 |
Fitzgerald |
50 ug |
EUR 281 |
|
Description: Rabbit polyclonal SOX2 antibody |
SOX2 antibody |
|
10R-11127 |
Fitzgerald |
100 ug |
EUR 349 |
|
Description: Mouse monoclonal SOX2 antibody |
SOX2 antibody |
|
70R-20460 |
Fitzgerald |
50 ul |
EUR 435 |
|
Description: Rabbit polyclonal SOX2 antibody |
SOX2 antibody |
|
70R-33158 |
Fitzgerald |
100 ug |
EUR 435 |
|
Description: Rabbit polyclonal SOX2 antibody |
SOX2 antibody |
|
70R-33160 |
Fitzgerald |
100 ug |
EUR 435 |
|
Description: Rabbit polyclonal SOX2 antibody |
SOX2 antibody |
|
70R-12166 |
Fitzgerald |
100 ug |
EUR 403 |
|
Description: Rabbit polyclonal SOX2 antibody |
Sox2 antibody |
|
70R-SR013 |
Fitzgerald |
100 ug |
EUR 300 |
|
Description: Affinity purified Rabbit polyclonal Sox2 antibody |
SOX2 Antibody |
|
5583-002mg |
ProSci |
0.02 mg |
EUR 171.82 |
|
|
|
Description: SOX2 Antibody: SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. SOX2 is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. The role of SOX2 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing SOX2 and the transcription factors POU5F1, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. Other experiments have shown that iPS cells could be generated using expression plasmids expressing POU5F1, SOX2, KlfF4 and c-Myc, eliminating the need for virus introduction. |
SOX2 Antibody |
|
5583-01mg |
ProSci |
0.1 mg |
EUR 436.42 |
|
|
|
Description: SOX2 Antibody: SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. SOX2 is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. The role of SOX2 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing SOX2 and the transcription factors POU5F1, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. Other experiments have shown that iPS cells could be generated using expression plasmids expressing POU5F1, SOX2, KlfF4 and c-Myc, eliminating the need for virus introduction. |
 (SOX2/1791) Antibody) SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC041791-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF405S conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC041791-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF405S conjugate, Concentration: 0.1mg/mL |
 (SOX2/1792) Antibody) SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC041792-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF405S conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC041792-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF405S conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC431792-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF543 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC471791-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF647 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC471791-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF647 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC471792-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF647 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC471792-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF647 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNCAP1791-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNCAP1791-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNCAP1792-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNCAP1792-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC801791-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF680 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC801791-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF680 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC801792-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF680 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC801792-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF680 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC811791-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF680R conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC811791-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF680R conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC811792-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF680R conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC811792-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF680R conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC681791-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF568 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC681791-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF568 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC681792-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF568 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC681792-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF568 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC701791-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF770 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC701791-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF770 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC701792-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF770 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC701792-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF770 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC881791-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF488A conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC881791-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF488A conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC881792-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF488A conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC881792-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF488A conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC611791-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF660R conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC611791-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF660R conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC611792-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF660R conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC611792-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF660R conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC941791-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF594 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC941791-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF594 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC941792-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF594 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC941792-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF594 conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNCA1791-250 |
Biotium |
250uL |
EUR 383 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),APC conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNCA1792-250 |
Biotium |
250uL |
EUR 383 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),APC conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNUB1791-100 |
Biotium |
100uL |
EUR 209 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791), Concentration: 0.2mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNUB1791-500 |
Biotium |
500uL |
EUR 458 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791), Concentration: 0.2mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNUB1792-100 |
Biotium |
100uL |
EUR 209 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792), Concentration: 0.2mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNUB1792-500 |
Biotium |
500uL |
EUR 458 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792), Concentration: 0.2mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNUM1791-50 |
Biotium |
50uL |
EUR 395 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791), 1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNUM1792-50 |
Biotium |
50uL |
EUR 395 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792), 1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNCH1791-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNCH1791-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNCH1792-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNCH1792-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC051791-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF405M conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNC051791-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),CF405M conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC051792-100 |
Biotium |
100uL |
EUR 199 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF405M conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNC051792-500 |
Biotium |
500uL |
EUR 544 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),CF405M conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNCP1791-250 |
Biotium |
250uL |
EUR 383 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),PerCP conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNCP1792-250 |
Biotium |
250uL |
EUR 383 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),PerCP conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1791) Antibody |
|
BNCR1791-250 |
Biotium |
250uL |
EUR 383 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1791),RPE conjugate, Concentration: 0.1mg/mL |
SOX2 (Transcription Factor) (SOX2/1792) Antibody |
|
BNCR1792-250 |
Biotium |
250uL |
EUR 383 |
|
Description: Primary antibody against SOX2 (Transcription Factor) (SOX2/1792),RPE conjugate, Concentration: 0.1mg/mL |
