Impaired phagocytic function in CX3CR1 + tissue-resident skeletal muscle macrophages prevents muscle recovery after influenza A virus-induced pneumonia in old mice
August 20, 2020

Impaired phagocytic function in CX3CR1 + tissue-resident skeletal muscle macrophages prevents muscle recovery after influenza A virus-induced pneumonia in old mice

By Matsuoka

the victim’s skeletal muscle dysfunction pneumonia disproportionately affects older individuals among major cause considerable morbidity. We found that the recovery of the skeletal muscle is impaired in elderly compared with young mice after the influenza A virus-induced pneumonia. In young mice, the recovery of muscle loss associated with the expansion of skeletal muscle tissue macrophage-resident and downregulation of the expression of MHC II, followed by a proliferation of muscle satellite cells.

These findings are not present in older rats and mice that lacked Cx3cr1. transcriptomic profiling of tissue-resident macrophages skeletal muscle of old compared to young rats showed downregulation of pathways associated with phagocytosis and proteostasis and continuous upregulation of inflammatory pathways. Consistently, skeletal muscle macrophages from old mice failed to downregulate the expression of MHCII during recovery from influenza

A virus-induced pneumonia and show impaired phagocytic function in vitro. Like the old animals, phagocytic receptor deficient mice did not show expansion Mertk macrophages, MHCII downregulation, or satellite cell proliferation and failed to recover the skeletal muscle function after influenza A pneumonia. Our data indicate that the loss of phagocytic function in a network-resident population of macrophages muscle order blocking rat CX3CR1 + in the old satellite cell proliferation and restoration of skeletal muscle function after influenza A pneumonia.


A phytochemical investigation Polygonatum odoratum root cause isolation fifteen steroid glycosides (1-15), three homoisoflavanones (16-18) and four cinnamic acid derivatives (19-22). The structure of all the compounds isolated are established primarily by spectroscopic analysis and chemical evidence required, the 1-8 (polygodorasides A-G) is identified as a new steroid glycosides. Among isolates, compounds 7 and 17 showed remarkable in vitro inhibitory effect against influenza viruses with IC50 values ​​of 14.30 and 49.70 mM (positive control ribavirin 28.4 M).

 Impaired phagocytic function in CX3CR1 + tissue-resident skeletal muscle macrophages prevents muscle recovery after influenza A virus-induced pneumonia in old mice
Impaired phagocytic function in CX3CR1 + tissue-resident skeletal muscle macrophages prevents muscle recovery after influenza A virus-induced pneumonia in old mice

phylogenetic characterization of the influenza A H5N2 reassortant virus from Mexico resident ducks (Anas diazi)

Congregation different migration and resident bird species in aquatic ecosystems during the winter migration increased level of contact and Improving influenza A virus (IAV) transmission. However, research has focused on the contribution of rare birds for virus ecology citizens on a local scale.

Mexican duck (Anas diazi) is anatid endangered endemic of Mexico. This resident species shares aquatic habitat by migratory birds in the wetlands of Central Mexico. Therefore, here we describe the phylogenetic analysis of IAV (A / Mexicanduck / EstadodeMexico; Lerma / UIFMVZ377 / 2016 (H5N2)) were isolated in this species, as long as spatiotemporal agreement with anatids migrate in winter. All eight gene sequences obtained by nextgeneration sequencing.

2019-nCoV IgG/IgM Rapid Test Cassette (Whole Blood/Serum/Plasma)

GEN-402-25tests 25 tests
EUR 292.8
Description: A rapid test for detection of antibodies (IgG and IgM) for 2019-nCoV, the novel Coronavirus from the Wuhan strain. The test is easy to perform, takes 10 minutes to provide reliable results and is higly specific to the 2019-nCoV Coronavirus.

Salt Testing Kit?(1pk=10 kits)

K052-1PK 1 unit
EUR 25.53
Description: Salt Testing Kit?(1pk=10 kits)

Human TES(Testin) ELISA Kit

EH1738 96T
EUR 681.12
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Homo sapiens;Sensitivity: 0.375 ng/ml

T(Testosterone) ELISA Kit

EU0400 96T
EUR 571.5
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: General;Sensitivity: 0.188 ng/ml

Rat T(Testosterone) ELISA Kit

ER1462 96T
EUR 628.92
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Rattus;Sensitivity: 0.188 ng/ml

Mouse Testosterone ELISA Kit

EM1850 96T
EUR 628.92
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Mus ;Sensitivity: 0.188 ng/ml

Human Testosterone ELISA Kit

EH4850 96T
EUR 628.92
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Homo sapiens ;Sensitivity: 0.188 ng/ml

Bovine T(Testosterone) ELISA Kit

EB0049 96T
EUR 681.12
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Cattle;Sensitivity: 0.188 ng/ml

Human SPOCK2(Testican-2) ELISA Kit

EH2271 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

Human TEX101(testis expressed 101) ELISA Kit

EH12903 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens ;Sensitivity: 0.188 ng/ml

Human F-TESTO(Free Testoterone) ELISA Kit

EH3092 96T
EUR 571.5
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Recombinant human Testin

P2531 100ug Ask for price
Description: Recombinant protein for human Testin

Recombinant human Testican-2

P1475 100ug Ask for price
Description: Recombinant protein for human Testican-2

Recombinant human Testis-specific Y-encoded-like protein 5

P1359 100ug Ask for price
Description: Recombinant protein for human Testis-specific Y-encoded-like protein 5

Rat Pdha2(Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial) ELISA Kit

ER0417 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 46.9pg/ml

Human PDHA2(Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial) ELISA Kit

EH1149 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Recombinant human Protein disulfide-isomerase-like protein of the testis

P2148 100ug Ask for price
Description: Recombinant protein for human Protein disulfide-isomerase-like protein of the testis

Soil Micronutrient Test Kit (Six Test Pa

K095L-1KT 1 unit
EUR 83.1
Description: Soil Micronutrient Test Kit (Six Test Pa

Soil Micronutrient Test Kit (Six Test Pa

K095M-1KT 1 unit
EUR 50.75
Description: Soil Micronutrient Test Kit (Six Test Pa

Melamine Rapid Test Kit Card (test cassette)

C400002 50T
EUR 85
Description: Milk Test

EdU Imaging Kits (488)

K1175-50 50-500 tests
EUR 240
Description: EdU Imaging Kits (488) is a sensitive and reliable way to detect and quantify cell proliferation in cells. It is optimized for fluorescence microscopy. It is a better alternative to traditional BrdU (bromodeoxyuridine).

BSA Standard kits

TBS5002 7x 1ml
EUR 45

Soil Test Kit

K054-1KT 1 unit
EUR 62.03
Description: Soil Test Kit

Soil Test Kit

K054L-1KT 1 unit
EUR 109.52
Description: Soil Test Kit

HiWater Test Kit

K015-10KT 1 unit
EUR 27.8
Description: HiWater Test Kit

HiSurba Test Kit

K060-1PK 1 unit
EUR 18.91
Description: HiSurba Test Kit

Arsenic Test Kit

WT025-1NO 1 unit
EUR 23.69
Description: Arsenic Test Kit

Quinolones(QNS) ELISA Test Kit Fluoroquinolone ELISA Test Kit

LSY-10016 96 well/kit Ask for price

Glyphosate test kit

N029 96T
EUR 100
Description: Milk Test

NOVATest IgG/IgM Antibody Rapid Test Kit (NOVA Test)

UNCOV-40 40 Tests
EUR 115

COVID-19 RNA Test, 1 test/pack

U20250 test Ask for price

T&A Cloning Kits

FYC001-20P 1 vial Ask for price

Cow Milk Test Kit (test cow milk from camel milk)

410003 96T
EUR 200
Description: Milk Test

HBsAg Test Card (Test in Whole Blood)

HBsAg-214 4.0mm (strip in a card) 25cards/box
EUR 0.2

HBsAg Test Strip (Test in Whole Blood)

HBsAg-213 3.0mm (single pouch) 100pouches/box
EUR 0.1

Human Anti-Chikungunya virus (CHIKV) IgM capture ELISA kits, 96 tests, qualitative

910-705-CHM 1 Kit
EUR 1000.8

EdU Imaging Kits (Cy3)

K1075-50 50-500 tests
EUR 240
Description: EdU Imaging Kits (Cy3) is a sensitive and reliable way to detect and quantify cell proliferation in cells. It is optimized for fluorescence microscopy. It is a better alternative to traditional BrdU (bromodeoxyuridine).

EdU Imaging Kits (Cy5)

K1076-50 50-500 tests
EUR 240
Description: EdU Imaging Kits (Cy5) is a sensitive and reliable way to detect and quantify cell proliferation in cells. It is optimized for fluorescence microscopy. It is a better alternative to traditional BrdU (bromodeoxyuridine).

Rat MTL5(Tesmin) ELISA Kit

ER1521 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 18.75pg/ml

rat LBP test kit

043a reagents for 96 wells
EUR 440

TC Combo Test Kit

N018 96T
EUR 100
Description: Milk Test

Octo Aqua Test Kit

WT023-1NO 1 unit
EUR 60.81
Description: Octo Aqua Test Kit

DPF Combo Test Kit

100041 96T
EUR 120
Description: Milk Test

NOVATest Antigen Rapid Test Kit (For Single Use) (NOVA Test)

nCov-500-01 1T
EUR 162

TBQSM 5in1 Test Kit

100057 96T
EUR 150
Description: Milk Test

Lead Rapid Test Kit

700001 96T
EUR 200
Description: Feed Test

TriTest BTS Test Kit

140015 96T
EUR 100
Description: Milk Test

Necrosis vs Apoptosis Kits

KF17371 50-100 Tests
EUR 522

Necrosis vs Apoptosis Kits

KF17372 100-200 Tests
EUR 921.6

HiStaph Latex Test Kit

LK03-100NO 1 unit
EUR 120.48
Description: HiStaph Latex Test Kit

HiStaph Latex Test Kit

LK03-50NO 1 unit
EUR 78.27
Description: HiStaph Latex Test Kit

Estriol Rapid Test Kit

100058 96T
EUR 100
Description: Milk Test

Tylosin ELISA Test Kit

LSY-10020 96 well/kit Ask for price

Cow Milk Test Kit (test cow milk from goat/sheep milk)

400003 96T
EUR 200
Description: Milk Test

Cow Milk Test Kit (test cow/goat milk from camel milk)

420003 96T
EUR 250
Description: Milk Test

Test product

testttt 0 Ask for price

Test Product

ZX001 1mg Ask for price
Description: Web testing purposes only.

Test Product

ZX002 5mg Ask for price
Description: Web testing purposes only.

Melamine Rapid Test Kit

abx092011-50tests 50 tests
EUR 444

Caffeine Rapid Test Kit

abx092240-100l 100 µl
EUR 387.5

Caffeine Rapid Test Kit

abx092240-1ml 1 ml
EUR 3600

Caffeine Rapid Test Kit

abx092240-200l 200 µl
EUR 1050

Melamine Rapid Test Kit

abx092011-100l 100 µl
EUR 175

Melamine Rapid Test Kit

abx092011-1ml 1 ml
EUR 437.5

Melamine Rapid Test Kit

abx092011-200l 200 µl
EUR 287.5

Neomycin Rapid Test Kit

100010 96T
EUR 85
Description: Milk Test

Colistin Rapid Test Kit

100026 96T
EUR 100
Description: Milk Test

Flunixin Rapid Test Kit

100028 96T
EUR 85
Description: Milk Test

Melamine Rapid Test Kit

400002 96T
EUR 100
Description: Milk Test

Paraquat Rapid Test Kit

N002 96T
EUR 100
Description: Milk Test

Carbaryl Rapid Test Kit

N007 96T
EUR 100
Description: Milk Test

Fipronil Rapid Test Kit

N013 96T
EUR 100
Description: Milk Test

Neomycin ELISA test kit

LSY-10005 96 well/kit Ask for price

Diazepam ELISA Test Kit

LSY-10021 96 well/kit Ask for price

Melamine ELISA test kit

LSY-10026 96 well/kit Ask for price

Colistin ELISA Test Kit

LSY-10056 96 well/kit Ask for price

Urinary Indican Test Kit

I1000N 20
EUR 309

Estradiol Rapid Test Kit

100055 96T
EUR 100
Description: Milk Test

Natamycin Rapid Test Kit

101305 96T
EUR 120
Description: Milk Test

Cefalexin Rapid Test Kit

E1012 96T
EUR 120
Description: Egg Test

Ofloxacin ELISA Test Kit

LSY-10064 96 well/kit Ask for price

Cefalexin ELISA Test Kit

LSY-10067 96 well/kit Ask for price

Adenovirus Rapid Test Kit

abx092253-100l 100 µl
EUR 1925

Adenovirus Rapid Test Kit

abx092253-1ml 1 ml
EUR 26250

Adenovirus Rapid Test Kit

abx092253-200l 200 µl
EUR 6600

Salbutamol Rapid Test Kit

abx092043-100l 100 µl
EUR 175

Salbutamol Rapid Test Kit

abx092043-1ml 1 ml
EUR 400

Salbutamol Rapid Test Kit

abx092043-200l 200 µl
EUR 262.5

Lincomycin Rapid Test Kit

100005 96T
EUR 85
Description: Milk Test

Gentamicin Rapid Test Kit

100011 96T
EUR 85
Description: Milk Test

Spiramycin Rapid Test Kit

100031 96T
EUR 85
Description: Milk Test

Avermectin Rapid Test Kit

100045 96T
EUR 100
Description: Milk Test

Bacitracin Rapid Test Kit

100046 96T
EUR 85
Description: Milk Test

Salbutamol Rapid Test Kit

100061 96T
EUR 100
Description: Milk Test

Olaquindox Rapid Test Kit

100062 96T
EUR 120
Description: Milk Test

Metamizole Rapid Test Kit

100064 96T
EUR 120
Description: Milk Test

Pirlimycin Rapid Test Kit

100066 96T
EUR 100
Description: Milk Test

Macrolides Rapid Test Kit

100323 48T
EUR 90
Description: Honey Test

Albendazol Rapid Test Kit

300001 96T
EUR 100
Description: Milk Test

Cyromazine Rapid Test Kit

N006 96T
EUR 100
Description: Milk Test

Carbofuran Rapid Test Kit

N010 96T
EUR 100
Description: Milk Test

Salbutamol ELISA Test Kit

LSY-10014 96 well/kit Ask for price

Ampicillin ELISA Test Kit

LSY-10018 96 well/kit Ask for price

Gentamicin ELISA Test Kit

LSY-10023 96 well/kit Ask for price

Olaquindox ELISA Test Kit

LSY-10025 96 well/kit Ask for price

Lincomycin ELISA Test Kit

LSY-10045 96 well/kit Ask for price

Amantadine ELISA test kit

LSY-10052 96 well/kit Ask for price

Tilmicosin ELISA test kit

LSY-10053 96 well/kit Ask for price

Avermectin ELISA test kit

LSY-10060 96 well/kit Ask for price

HiRotavirus Latex Test Kit

LK08-10NO 1 unit
EUR 39.14
Description: HiRotavirus Latex Test Kit

HiRotavirus Latex Test Kit

LK08-25NO 1 unit
EUR 96.29
Description: HiRotavirus Latex Test Kit

HiRotavirus Latex Test Kit

LK08-50NO 1 unit
EUR 188.06
Description: HiRotavirus Latex Test Kit

Clenbuterol Rapid Test Kit

abx092040-100l 100 µl
EUR 150

Clenbuterol Rapid Test Kit

abx092040-1ml 1 ml
EUR 337.5

Clenbuterol Rapid Test Kit

abx092040-200l 200 µl
EUR 225

Ractopamine Rapid Test Kit

abx092042-100l 100 µl
EUR 150

Ractopamine Rapid Test Kit

abx092042-1ml 1 ml
EUR 337.5

Ractopamine Rapid Test Kit

abx092042-200l 200 µl
EUR 225

Zearalenone Rapid Test Kit

abx092051-100l 100 µl
EUR 187.5

Zearalenone Rapid Test Kit

abx092051-1ml 1 ml
EUR 487.5

Zearalenone Rapid Test Kit

abx092051-200l 200 µl
EUR 325

Florfenicol Rapid Test Kit

100032 96T
EUR 85
Description: Milk Test

Clenbuterol Rapid Test Kit

100059 96T
EUR 100
Description: Milk Test

Ractopamine Rapid Test Kit

100060 96T
EUR 100
Description: Milk Test

Carbendazim Rapid Test Kit

100334 48T
EUR 90
Description: Honey Test

Acetamiprid Rapid Test Kit

100335 48T
EUR 90
Description: Honey Test

Florfenicol Rapid Test Kit

E1020 96T
EUR 120
Description: Egg Test

Carbendazim Rapid Test Kit

N001 96T
EUR 100
Description: Milk Test

Acetamiprid Rapid Test Kit

N004 96T
EUR 100
Description: Milk Test

Doxycycline ELISA Test Kit

DEIARN99048 96T
EUR 1365
Description: feed, tissue(meat,liver and kidney), milk, serum,plasma and urine

Florfenicol ELISA Test Kit

LSY-10008 96 well/kit Ask for price

Clenbuterol ELISA Test Kit

LSY-10012 96 well/kit Ask for price

Ractopamine ELISA Test Kit

LSY-10013 96 well/kit Ask for price

Zearalenone ELISA test kit

LSY-10030 96 well/kit Ask for price

Doxycycline ELISA test kit

LSY-10051 96 well/kit Ask for price

Amoxicillin ELISA Test Kit

LSY-10054 96 well/kit Ask for price

Nicarbazine ELISA test kit

LSY-10063 96 well/kit Ask for price

Pyrazinamidase Test Kit for

K045-KT 1 unit
EUR 18.31
Description: Pyrazinamidase Test Kit for

HiLegionella Latex Test Kit

LK04-25NO 1 unit
EUR 119.46
Description: HiLegionella Latex Test Kit

HiLegionella Latex Test Kit

LK04-50NO 1 unit
EUR 220.56
Description: HiLegionella Latex Test Kit

Sulfonamides Rapid Test Kit

abx092047-100l 100 µl
EUR 287.5

Sulfonamides Rapid Test Kit

abx092047-1ml 1 ml
EUR 625

Sulfonamides Rapid Test Kit

abx092047-200l 200 µl
EUR 450

Tetracycline Rapid Test Kit

abx092048-100l 100 µl
EUR 250

Tetracycline Rapid Test Kit

abx092048-1ml 1 ml
EUR 562.5

Tetracycline Rapid Test Kit

abx092048-200l 200 µl
EUR 375

Sulfonamides Rapid Test Kit

100008 96T
EUR 85
Description: Milk Test

Streptomycin Rapid Test Kit

100012 96T
EUR 85
Description: Milk Test

Progesterone Rapid Test Kit

100047 96T
EUR 100
Description: Milk Test

Erythromycin Rapid Test Kit

100065 96T
EUR 100
Description: Milk Test

Trimethoprim Rapid Test Kit

100070 96T
EUR 100
Description: Milk Test

Progesterone Rapid Test Kit

102205 96T
EUR 100
Description: Milk Test

Sulfonamides Rapid Test Kit

E1014 96T
EUR 120
Description: Egg Test

Imidacloprid Rapid Test Kit

N005 96T
EUR 100
Description: Milk Test

Thiamethoxam Rapid Test Kit

N008 96T
EUR 100
Description: Milk Test

Enrofloxacin ELISA Test Kit

LSY-10017 96 well/kit Ask for price

Maximum Likelihood tree constructed using MEGA-X, with General Time Reversible + Invariant (GTR + I), subtree pruning and Regrafting (SPR) heuristic method, and 1000 bootstrap replications. IAV similarities with six different subtypes observed through BLAST search: H6N5, H7N7, H5N2, H4N6, H9N2, and H11N9, was detected in wild ducks during 2015 at a site to stop the Pacific, Central and Mississippi flyways throughout the United States and Canada. IAV molecular identification reassortant H5N2 highlights the importance of resident species as the host reservoirs and their potential participation in the maintenance and transmission of IAV in wetlands surrounded by countryside.