influenza-x
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September 25, 2020

RNA SNHG15 regulates cardiomyocyte apoptosis after hypoxia/reperfusion damage

By Matsuoka

Integrative evaluation of lengthy non-coding RNA and mRNA in broilers with valgus-varus deformity

 

Background: Bone abnormality and leg illness in business broiler flocks are more and more outstanding, inflicting critical financial losses to the broiler breeding business. Valgus-varus deformity (VVD) is a standard deformity of the lengthy bone in broilers that manifests as an outward or inward deviation of the tibiotarsus or tarsometatarsus. There’s a paucity of research on the molecular mechanisms of VVD.

 

Outcomes: On this research, 6 cDNA libraries had been constructed from spleen samples from VVD birds and regular birds. A complete of 1951 annotated lncRNAs, 7943 novel lncRNAs and 30252 mRNAs had been recognized by RNA-sequencing. As well as, 420 differentially expressed (DE) mRNAs and 124 differentially expressed lncRNAs (adjusted P-value < 0.05) had been obtained.

 

A complete of 16 dysregulated genes had been confirmed by qPCR to be in line with the outcomes of the RNA-Seq. The purposeful lncRNA-mRNA co-expression community was constructed utilizing differentially expressed mRNAs and goal genes of the differentially expressed lncRNAs. 11 DE genes had been obtained from the evaluation. With a view to achieve perception into the interactions of genes, lncRNAs and pathways related to VVD, we targeted on the next pathways, that are concerned in immunity and bone growth:

 

the Jak-stat signaling pathway, Toll-like receptor signaling pathway, Wnt-signaling pathway, mTOR signaling pathway, VEGF signaling pathway, Notch signaling pathway, TGF-beta signaling pathway and Fanconi anemia pathway. All collectively, 30 candidate DE genes had been obtained from these pathways. We then analyzed the interplay between the DE genes and their corresponding lncRNAs. From these interplay community analyses we discovered that GARS, NFIC, PIK3R1, BMP6, NOTCH1, ACTB and CREBBP had been the important thing core nodes of those networks.

 

Conclusion: This research confirmed that differentially expressed genes and signaling pathways had been associated to immunity or bone growth. These outcomes improve the understanding of the molecular mechanisms of VVD and supply some reference for the etiology and pathogenesis of VVD.

influenza-x

Human BDNF
MBS691492-0002mg 0.002mg
EUR 300

Human BDNF
MBS691492-001mg 0.01mg
EUR 450

Human BDNF
MBS691492-5x001mg 5x0.01mg
EUR 1725

BDNF (human)
B5341-.01 10 ug
EUR 711.6

BDNF, Human
HY-P7116A 50ug
EUR 914.4

BDNF， Human
E34M135H 5 μg
EUR 155

BDNF (Human)
MBS5789515-INQUIRE INQUIRE Ask for price

BDNF, Human
MBS8575292-0005mg 0.005mg
EUR 245

BDNF, Human
MBS8575292-5x0005mg 5x0.005mg
EUR 940

BDNF (human)
TP2069-10mg 10mg Ask for price
Description: BDNF (human)

BDNF (human)
TP2069-1g 1g Ask for price
Description: BDNF (human)

BDNF (human)
TP2069-1mg 1mg Ask for price
Description: BDNF (human)

BDNF (human)
TP2069-50mg 50mg Ask for price
Description: BDNF (human)

BDNF (human)
TP2069-5mg 5mg Ask for price
Description: BDNF (human)

Anti-Human BDNF Antibody
101-M138 100 µg
EUR 399
Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 119 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

Anti-Human BDNF Antibody
101-M139 100 µg
EUR 399
Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 119 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

Anti-Human BDNF Antibody
101-M229 100 µg
EUR 399
Description: Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous system. The neurotrophin family comprises at least four proteins including NGF, BDNF, NT3, and NT4/ 5. These secreted cytokines are synthesized as prepropeptides that are proteolytically processed to generate the mature proteins. All neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds and all share approximately 55% sequence identity at the amino acid level. Similarly to NGF, bioactive BDNF is predicted to be a noncovalently linked homodimer. BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. The amino acid sequence of mature BDNF is identical in all mammals examined. High levels of expression of BDNF have been detected in the hippocampus, cerebellum, fetal eye, and placenta. In addition, low levels of BDNF expression are also found in the pituitary gland, spinal cord, heart, lung, and skeletal muscle. BDNF binds with high affinity and specifically activates the TrkB tyrosine kinase receptor.

Anti-Human BDNF Antibody
102-P02 100 µg
EUR 245.7
Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 119 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

Anti-Human BDNF Antibody
MBS1569902-01mg 0.1mg
EUR 375

Anti-Human BDNF Antibody
MBS1569902-5x01mg 5x0.1mg
EUR 1390

Antibody for Human BDNF
SPC-703D-A565 0.1mg
EUR 480
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 565.

Antibody for Human BDNF
SPC-703D-A633 0.1mg
EUR 480
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 633.

Antibody for Human BDNF
SPC-703D-A655 0.1mg
EUR 480
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 655.

Antibody for Human BDNF
SPC-703D-A680 0.1mg
EUR 480
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 680.

Antibody for Human BDNF
SPC-703D-A700 0.1mg
EUR 480
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to ATTO 700.

Antibody for Human BDNF
SPC-703D-APCCY7 0.1mg
EUR 565.2
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to APC/Cy7.

Antibody for Human BDNF
SPC-703D-DY350 0.1mg
EUR 496.8
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Dylight 350.

Antibody for Human BDNF
SPC-703D-DY405 0.1mg
EUR 483.6
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Dylight 405.

Antibody for Human BDNF
SPC-703D-DY488 0.1mg
EUR 471.6
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Dylight 488.

Antibody for Human BDNF
SPC-703D-DY594 0.1mg
EUR 474
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Dylight 594.

Antibody for Human BDNF
SPC-703D-DY633 0.1mg
EUR 468
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Dylight 633.

Antibody for Human BDNF
SPC-703D-P594 0.1mg
EUR 488.4
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to PE/ATTO 594.

Antibody for Human BDNF
SPC-703D-STR 0.1mg
EUR 477.6
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Streptavidin.

Human BDNF siRNA
20-abx900619
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

Rabbit Anti Human BDNF Monoclonal Clone BEH-2
IRBAHUBDNFBEH2C100UL each
EUR 496
Description: Rabbit Anti Human BDNF Monoclonal Clone BEH-2

Human BDNF Protein
E2PD201135 20ug
EUR 595

BDNF siRNA (Human)
MBS8230608-15nmol 15nmol
EUR 405

BDNF siRNA (Human)
MBS8230608-30nmol 30nmol
EUR 565

BDNF siRNA (Human)
MBS8230608-5x30nmol 5x30nmol
EUR 2450

RECOMBINANT HUMAN BDNF
GWB-DE906C 0.01 mg Ask for price

recombinant human BDNF
E4A10L10 100ug
EUR 595

Recombinant Human BDNF
MBS4159636-001mg 0.01mg
EUR 385

Recombinant Human BDNF
MBS4159636-1mg 1(mg)
EUR 7935

RECOMBINANT HUMAN BDNF
MBS232457-001mg 0.01mg
EUR 520

RECOMBINANT HUMAN BDNF
MBS232457-5x001mg 5x0.01mg
EUR 2160

Recombinant Human BDNF
MBS7608556-005mg 0.05mg
EUR 345

Recombinant Human BDNF
MBS7608556-02mg 0.2mg
EUR 635

Recombinant Human BDNF
MBS7608556-1mg 1mg
EUR 1800

Recombinant Human BDNF
MBS7608556-5x1mg 5x1mg
EUR 6955

Recombinant Human BDNF
MBS7609632-005mg 0.05mg
EUR 345

Recombinant Human BDNF
MBS7609632-02mg 0.2mg
EUR 635

Recombinant Human BDNF
MBS7609632-1mg 1mg
EUR 1800

Recombinant Human BDNF
MBS7609632-5x1mg 5x1mg
EUR 6955

Recombinant Human BDNF
Z100065 10 µg
EUR 235
Description: BDNF is found in neurons of the central nervous system. It is expressed predominantly in hippocampus, cortex, and synapses of the basal forebrain. The biological activity of BDNF is mediated by a receptor that belongs to the trk family of receptors encoding a tyrosine-specific protein kinase. BDNF only binds weakly to the gp140trk receptor (to which NGF binds with high affinity), and it binds to the NGF receptor known as LNGFR. BDNF selectively supports the survival of primary sensory neurons and retinal ganglia. The factor supports survival and differentiation of certain cholinergic neurons and also some dopaminergic neurons in vitro. BDNF does not appear to act on sympathetic ganglia. In specific neurons of the central nervous system located in the hippocampus and the cortex the synthesis of BDNF is influenced by neuronal activity either positively (glutamate transmitter system) or negatively (GABA transmitter system).

Recombinant Human BDNF
Z100069 1.0 mg
EUR 6900
Description: BDNF is found in neurons of the central nervous system. It is expressed predominantly in hippocampus, cortex, and synapses of the basal forebrain. The biological activity of BDNF is mediated by a receptor that belongs to the trk family of receptors encoding a tyrosine-specific protein kinase. BDNF only binds weakly to the gp140trk receptor (to which NGF binds with high affinity), and it binds to the NGF receptor known as LNGFR. BDNF selectively supports the survival of primary sensory neurons and retinal ganglia. The factor supports survival and differentiation of certain cholinergic neurons and also some dopaminergic neurons in vitro. BDNF does not appear to act on sympathetic ganglia. In specific neurons of the central nervous system located in the hippocampus and the cortex the synthesis of BDNF is influenced by neuronal activity either positively (glutamate transmitter system) or negatively (GABA transmitter system).

anti- BDNF antibody
FNab10014 100µg
EUR 658.5
Description: Antibody raised against BDNF

anti- BDNF antibody
FNab00859 100µg
EUR 606.3
Description: Antibody raised against BDNF

Rabbit anti-Homo sapiens (Human) BDNF Polyclonal Antibody
MBS7138282-INQUIRE INQUIRE Ask for price

BDNF, human recombinant
4004-10 each
EUR 333.6

BDNF, human recombinant
4004-1000 each
EUR 6571.2

BDNF, human recombinant
4004-250 each
EUR 2461.2

BDNF, human recombinant
4004-50 each
EUR 816

BDNF, human recombinant
P1007-.01 10 µg
EUR 273.6
Description: Neurotrophins|Brain-Derived Neurotrophic Factor

BDNF, human recombinant
P1007-.05 50 µg
EUR 658
Description: BDNF, expressed in E. coli, a potent neurotrophic factor.

BDNF, human recombinant
P1007-.1 100ug
EUR 900.8
Description: Neurotrophins|Brain-Derived Neurotrophic Factor

BDNF, human recombinant
P1007-.25 250 µg
EUR 2050
Description: BDNF, expressed in E. coli, a potent neurotrophic factor.

BDNF, human recombinant
P1007-1 1 mg
EUR 5530
Description: BDNF, expressed in E. coli, a potent neurotrophic factor.

Human BDNF ELISA Kit
55R-1556 1 kit
EUR 615
Description: ELISA kit for detection of BDNF in the research laboratory

Human BDNF ELISA Kit
CEK1016 96T
EUR 538
Description: Sandwich ELKSA for quantitative detection of Human BDNF concentrations.

Human BDNF ELISA Kit
ELA-E0011h 96 Tests
EUR 988.8

Human BDNF ELISA Kit
GWB-SKR197 96 Tests Ask for price

Human BDNF ELISA Kit
GWB-ZZD022 1x96 well plate Ask for price

Human BDNF ELISA Kit
K0332152 96well
EUR 271
Description: https://komabiotech.co.kr/labiskoma/datasheet/K0332152.pdf

Human BDNF ELISA Kit
E16HE0041 96T
EUR 833.33

Human BDNF ELISA Kit
E28L0224 96T
EUR 666.67

Human BDNF ELISA Kit
EK5126 96 tests
EUR 449

Human BDNF ELISA Kit
EHB0036 96Tests
EUR 625.2

Human BDNF ELISA kit
LF-EK50005 1×96T
EUR 777.6

Human BDNF ELISA Kit
MBS824804-5x96Tests 5x96Tests
EUR 2755

Human BDNF ELISA Kit
MBS824804-96Tests 96Tests
EUR 620

Human BDNF ELISA Kit
MBS9135790-5x96Tests 5x96Tests
EUR 2615

Human BDNF ELISA Kit
MBS9135790-96Tests 96Tests
EUR 570

Human BDNF ELISA Kit
STJ150202 1 kit
EUR 494.4
Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of BDNF in human serum, plasma and other biological fluids

Human, Rat, Mouse BDNF antibody
P0363 100ul
EUR 150

Mouse Monoclonal anti-Human BDNF
hAP-0109 100ug
EUR 250

Mouse Monoclonal anti-Human BDNF
hAP-0109A 100ug
EUR 250

Mouse Monoclonal anti-Human BDNF
hAP-0109B 100ug
EUR 250

InVivoMAb Anti-Human BDNF (Iv0093)
MBS1570123-01mg 0.1mg
EUR 405

InVivoMAb Anti-Human BDNF (Iv0093)
MBS1570123-5x01mg 5x0.1mg
EUR 1520

Rabbit Anti-Human BDNF Polyclonal
SPC-703D-ALP 0.1mg
EUR 377
Description: A polyclonal antibody for BDNF from Human | Mouse . The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of human BDNF. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This BDNF antibody is conjugated to Alkaline Phosphatase.

Rabbit Anti-Human BDNF Polyclonal
MBS807457-01mg 0.1mg
EUR 565

Rabbit Anti-Human BDNF Polyclonal
MBS807457-5x01mg 5x0.1mg
EUR 2000

Rabbit Anti-Human BDNF Polyclonal
MBS807483-01mg 0.1mg
EUR 520

Rabbit Anti-Human BDNF Polyclonal
MBS807483-5x01mg 5x0.1mg
EUR 1785

Rabbit Anti-Human BDNF Polyclonal
MBS807487-01mg 0.1mg
EUR 570

Rabbit Anti-Human BDNF Polyclonal
MBS807487-5x01mg 5x0.1mg
EUR 2025

Rabbit Anti-Human BDNF Polyclonal
MBS807503-01mg 0.1mg
EUR 570

Rabbit Anti-Human BDNF Polyclonal
MBS807503-5x01mg 5x0.1mg
EUR 2025

Rabbit Anti-Human BDNF Polyclonal
MBS807553-01mg 0.1mg
EUR 570

Rabbit Anti-Human BDNF Polyclonal
MBS807553-5x01mg 5x0.1mg
EUR 2020

Rabbit Anti-Human BDNF Polyclonal
MBS807570-01mg 0.1mg
EUR 555

Rabbit Anti-Human BDNF Polyclonal
MBS807570-5x01mg 5x0.1mg
EUR 1970

Rabbit Anti-Human BDNF Polyclonal
MBS807630-01mg 0.1mg
EUR 560

Rabbit Anti-Human BDNF Polyclonal
MBS807630-5x01mg 5x0.1mg
EUR 1990

Rabbit Anti-Human BDNF Polyclonal
MBS807632-01mg 0.1mg
EUR 565

Rabbit Anti-Human BDNF Polyclonal
MBS807632-5x01mg 5x0.1mg
EUR 2010

Rabbit Anti-Human BDNF Polyclonal
MBS807648-01mg 0.1mg
EUR 565

Rabbit Anti-Human BDNF Polyclonal
MBS807648-5x01mg 5x0.1mg
EUR 2005

Rabbit Anti-Human BDNF Polyclonal
MBS807679-01mg 0.1mg
EUR 570

Rabbit Anti-Human BDNF Polyclonal
MBS807679-5x01mg 5x0.1mg
EUR 2030

BDNF (NM_170734) Human Recombinant Protein
E45H35507M5 20 ug
EUR 785.42

Human BDNF Antibody (Biotin Conjugate)
32507-05121 150 ug
EUR 315

Human BDNF shRNA Plasmid
20-abx950425
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

BDNF ELISA KIT|Human
EF006120 96 Tests
EUR 826.8

BDNF (Human) ELISA Kit
EKA52013-5x96T 5x96T Ask for price

BDNF (Human) ELISA Kit
EKA52013-96T 96T
EUR 446.9

BDNF (human) ELISA Kit
K4788-100 each
EUR 1070.4

BDNF Human ELISA Kit
MBS355324-5x96Tests 5x96Tests
EUR 2050

BDNF Human ELISA Kit
MBS355324-96Tests 96Tests
EUR 455

Human BDNF Protein Lysate
MBS137924-002mg 0.02mg
EUR 365

 

 

Lengthy non-coding RNA SNHG15 regulates cardiomyocyte apoptosis after hypoxia/reperfusion damage through modulating miR-188-5p/PTEN axis

 

These days the simplest method to treatment myocardial infarction (MI) is reperfusion, which inevitably results in cardiomyocyte apoptosis. On this research, we mentioned the features of SNHG15 in regulating cardiomyocyte apoptosis by the modulation of miR-188-5p/PTEN axis.

We examined the hyperlinks between SNHG15 and miR-188-5p/PTEN in mice with MI. Intensive experiments, measurements and comparisons had been carried out, together with RT-PCR, western blotting, luciferase reporter assay, circulate cytometry evaluation and so on. By way of a sequence of comparisons and evaluation, we found that SNHG15 might work together with the miR-188-5p/PTEN axis and affect the mobile physiology of cardiomyocyte apoptosis.

PTEN was upregulated in hypoxia cells, however this impact was attenuated by miR-188-5p. MiR-188-5p might mix with SNHG15 and PTEN, and type a SNHG15-miR-188-5p-PTEN axis, which regulated the apoptosis of MCs. These outcomes recommend that LncRNA SNHG15 regulates cardiomyocyte apoptosis induced by hypoxia or reperfusion damage by modulating of miR-188-5p/PTEN axis.

 

Bio-activating ultrafine grain titanium: RNA sequencing reveals enhanced mechano-activation of osteoconduction on nanostructured substrates

 

  • Titanium is basically absent from organic programs but reliably integrates into bone. To attain osseointegration, titanium should activate organic processes with out getting into cells, defining it as a bio-activating materials. Nanostructuring bulk titanium reduces grain dimension, will increase power, and improves different quantifiable bodily properties, together with cytocompatibility.

 

  • The organic processes activated by growing grain boundary availability had been detected with whole RNA-sequencing in mouse pre-osteoblasts grown for 72 hours on nanometrically easy substrates of both coarse grain or nanostructured ultrafine grain titanium. The typical grain boundary size underneath cells on the standard coarse grain substrates is 273.Zero μm, in comparison with 70,881.5 μm for cells adhered to the nanostructured ultrafine grain substrates; a 260-fold distinction.

 

 

  • Cells on each substrates exhibit related expression profiles for genes whose merchandise are vital for mechanosensation and transduction of cues that set off osteoconduction. Organic course of Gene Ontology time period enrichment evaluation of differentially expressed genes reveals that cell cycle, chromatin modification, telomere upkeep, and RNA metabolism processes are upregulated on ultrafine grain titanium. Processes associated to immune response, together with apoptosis, are downregulated.

 

  • Tumor-suppressor genes are upregulated whereas tumor-promoting genes are downregulated. Upregulation of genes concerned in chromatin reworking and downregulation of genes underneath the management of the peripheral circadian clock implicate each processes within the transduction of mechanosensory info. Non-coding RNAs may play a task within the response.

 

 

  • Merging transcriptomics with well-established mechanobiology ideas generates a unified mannequin to clarify the bio-activating properties of titanium. The modulation of processes is achieved by chromatin reworking through which the nucleus responds like a rheostat to grain boundary focus. This convergence of organic and supplies science reveals a pathway towards understanding the biotic-abiotic interface and can inform the event of efficient bio-activating and bio-inactivating supplies.

Alternative Thioglycollate Medium
MU010G-500G 1 unit
EUR 23.49
Description: Alternative Thioglycollate Medium

Alternative Thioglycollate Medium
MU010G-5KG 1 unit
EUR 198.68
Description: Alternative Thioglycollate Medium

Alternative Thioglycollate Medium
MM010-100G 1 unit
EUR 9.83
Description: Alternative Thioglycollate Medium

Alternative Thioglycollate Medium
MM010-2.5KG 1 unit
EUR 73.81
Description: Alternative Thioglycollate Medium

Alternative Thioglycollate Medium
MM010-500G 1 unit
EUR 15.61
Description: Alternative Thioglycollate Medium

Alternative Thioglycollate Medium
MM010-5KG 1 unit
EUR 129.15
Description: Alternative Thioglycollate Medium

EZView Stain (Alternative to EB)
A4205-1ML 1ML
EUR 30.8
Description: Biotechnology

AOX1 | Algal Alternative oxidase 1
AS06-152 50 µl
EUR 302

EZView Stain, 20,000X (Alternative to EB)
A4209-1ML 1ML
EUR 55
Description: Biotechnology

Plant Alternative Oxidase ELISA Kit
ELA-E1413Pl 96tests
EUR 796

Alternative Thioglycollate Medium ?(NIH
GM010-500G 1 unit
EUR 19.53
Description: Alternative Thioglycollate Medium ?(NIH

L-Spreader alternative to blending
PW1085-1X100NO 1 unit
EUR 28.45
Description: L-Spreader alternative to blending

L-Spreader alternative to blending
PW1085-1X20NO 1 unit
EUR 6.6
Description: L-Spreader alternative to blending

L-Spreader alternative to blending
PW1085-1X50NO 1 unit
EUR 14.96
Description: L-Spreader alternative to blending

Alternative Thioglycollate Medium, Ster
MU010G-2.5KG 1 unit
EUR 110.34
Description: Alternative Thioglycollate Medium, Ster

Thioglycollate HiVeg Broth, Alternative
MV010-100G 1 unit
EUR 9.83
Description: Thioglycollate HiVeg Broth, Alternative

"Thioglycollate HiVeg Broth, Alternative
MV010-10KG 1 unit
EUR 279.29
Description: "Thioglycollate HiVeg Broth, Alternative

Thioglycollate HiVeg Broth, Alternative
MV010-500G 1 unit
EUR 16.96
Description: Thioglycollate HiVeg Broth, Alternative

Alternative Thioglycollate Medium, Steri
M010G-2.5KG 1 unit
EUR 103.95
Description: Alternative Thioglycollate Medium, Steri

Alternative Thioglycollate Medium, Steri
M010G-500G 1 unit
EUR 22.42
Description: Alternative Thioglycollate Medium, Steri

Alternative Thioglycollate Medium, Steri
M010G-5KG 1 unit
EUR 186.93
Description: Alternative Thioglycollate Medium, Steri

Rat Alternative Oxidase (ATO) ELISA Kit
MBS2603984-10x96StripWells 10x96-Strip-Wells
EUR 3290

Rat Alternative Oxidase (ATO) ELISA Kit
MBS2603984-48StripWells 48-Strip-Wells
EUR 295

Rat Alternative Oxidase (ATO) ELISA Kit
MBS2603984-5x96StripWells 5x96-Strip-Wells
EUR 1800

Rat Alternative Oxidase (ATO) ELISA Kit
MBS2603984-96StripWells 96-Strip-Wells
EUR 450

Rat Alternative Oxidase (AOX) ELISA Kit
MBS9348312-10x96StripWells 10x96-Strip-Wells
EUR 6725

Rat Alternative Oxidase (AOX) ELISA Kit
MBS9348312-48StripWells 48-Strip-Wells
EUR 550

Rat Alternative Oxidase (AOX) ELISA Kit
MBS9348312-5x96StripWells 5x96-Strip-Wells
EUR 3420

Rat Alternative Oxidase (AOX) ELISA Kit
MBS9348312-96StripWells 96-Strip-Wells
EUR 765

Cat Alternative Oxidase (AOX) ELISA Kit
MBS9359559-INQUIRE INQUIRE Ask for price

Sterile Alternative Thioglycollate Mediu
LQ028-10X100ML 1 unit
EUR 24.33
Description: Sterile Alternative Thioglycollate Mediu

Alternative Thioglycollate HiCynth Mediu
MCD010-100G 1 unit
EUR 11.3
Description: Alternative Thioglycollate HiCynth Mediu

Alternative Thioglycollate HiCynth Mediu
MCD010-500G 1 unit
EUR 19.53
Description: Alternative Thioglycollate HiCynth Mediu

Goat Alternative Oxidase (ATO) ELISA Kit
MBS2605211-10x96StripWells 10x96-Strip-Wells
EUR 3545

Goat Alternative Oxidase (ATO) ELISA Kit
MBS2605211-48StripWells 48-Strip-Wells
EUR 310

Goat Alternative Oxidase (ATO) ELISA Kit
MBS2605211-5x96StripWells 5x96-Strip-Wells
EUR 1940

Goat Alternative Oxidase (ATO) ELISA Kit
MBS2605211-96StripWells 96-Strip-Wells
EUR 475

Goat Alternative Oxidase (AOX) ELISA Kit
MBS9344499-INQUIRE INQUIRE Ask for price

Fish Alternative Oxidase (AOX) ELISA Kit
MBS9350772-INQUIRE INQUIRE Ask for price

Cavy Alternative Oxidase (AOX) ELISA Kit
MBS9347765-INQUIRE INQUIRE Ask for price

Duck Alternative Oxidase (AOX) ELISA Kit
MBS9357353-INQUIRE INQUIRE Ask for price

Alternative Thioglycollate Medium, Sterile
39422 100 Gms
EUR 4.28
Description: Part D

Alternative Thioglycollate Medium, Sterile
39422-1 500 Gms
EUR 18.82
Description: Part D

JC-10 *Superior alternative to JC-1*
22204-5x100uL 5x100 uL
EUR 109
Description: Although JC-1 is widely used in many labs, its poor water solubility makes it hard to use for some applications.

Alternative Thioglycollate Medium (NIH T
M010-2.5KG 1 unit
EUR 80.4
Description: Alternative Thioglycollate Medium (NIH T

Human Alternative Oxidase(ATO)ELISA Kit
EIA06754h each
EUR 430

Plant Alternative Oxidase (AOX) ELISA Kit
MBS108890-10x96StripWells 10x96-Strip-Wells
EUR 6725

Plant Alternative Oxidase (AOX) ELISA Kit
MBS108890-48StripWells 48-Strip-Wells
EUR 550

Plant Alternative Oxidase (AOX) ELISA Kit
MBS108890-5x96StripWells 5x96-Strip-Wells
EUR 3420

Plant Alternative Oxidase (AOX) ELISA Kit
MBS108890-96StripWells 96-Strip-Wells
EUR 765

Human Alternative Oxidase (ATO) ELISA Kit
MBS2604989-10x96StripWells 10x96-Strip-Wells
EUR 3040

Human Alternative Oxidase (ATO) ELISA Kit
MBS2604989-48StripWells 48-Strip-Wells
EUR 285

Human Alternative Oxidase (ATO) ELISA Kit
MBS2604989-5x96StripWells 5x96-Strip-Wells
EUR 1670

Human Alternative Oxidase (ATO) ELISA Kit
MBS2604989-96StripWells 96-Strip-Wells
EUR 405

Mouse Alternative Oxidase (ATO) ELISA Kit
MBS2606922-10x96StripWells 10x96-Strip-Wells
EUR 3290

Mouse Alternative Oxidase (ATO) ELISA Kit
MBS2606922-48StripWells 48-Strip-Wells
EUR 295

Mouse Alternative Oxidase (ATO) ELISA Kit
MBS2606922-5x96StripWells 5x96-Strip-Wells
EUR 1800

Mouse Alternative Oxidase (ATO) ELISA Kit
MBS2606922-96StripWells 96-Strip-Wells
EUR 450

Plant Alternative Oxidase (ATO) ELISA Kit
MBS2602605-10x96StripWells 10x96-Strip-Wells
EUR 3545

Plant Alternative Oxidase (ATO) ELISA Kit
MBS2602605-48StripWells 48-Strip-Wells
EUR 310

Plant Alternative Oxidase (ATO) ELISA Kit
MBS2602605-5x96StripWells 5x96-Strip-Wells
EUR 1940

Plant Alternative Oxidase (ATO) ELISA Kit
MBS2602605-96StripWells 96-Strip-Wells
EUR 475

Mouse Alternative Oxidase (AOX) ELISA Kit
MBS9343473-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse Alternative Oxidase (AOX) ELISA Kit
MBS9343473-48StripWells 48-Strip-Wells
EUR 550

Mouse Alternative Oxidase (AOX) ELISA Kit
MBS9343473-5x96StripWells 5x96-Strip-Wells
EUR 3420

Mouse Alternative Oxidase (AOX) ELISA Kit
MBS9343473-96StripWells 96-Strip-Wells
EUR 765

Sheep Alternative Oxidase (AOX) ELISA Kit
MBS9355679-10x96StripWells 10x96-Strip-Wells
EUR 6725

Sheep Alternative Oxidase (AOX) ELISA Kit
MBS9355679-48StripWells 48-Strip-Wells
EUR 550

Sheep Alternative Oxidase (AOX) ELISA Kit
MBS9355679-5x96StripWells 5x96-Strip-Wells
EUR 3420

Sheep Alternative Oxidase (AOX) ELISA Kit
MBS9355679-96StripWells 96-Strip-Wells
EUR 765

Camel Alternative Oxidase (AOX) ELISA Kit
MBS9353428-10x96StripWells 10x96-Strip-Wells
EUR 6725

Camel Alternative Oxidase (AOX) ELISA Kit
MBS9353428-48StripWells 48-Strip-Wells
EUR 550

Camel Alternative Oxidase (AOX) ELISA Kit
MBS9353428-5x96StripWells 5x96-Strip-Wells
EUR 3420

Camel Alternative Oxidase (AOX) ELISA Kit
MBS9353428-96StripWells 96-Strip-Wells
EUR 765

Human Alternative Oxidase (AOX) ELISA Kit
MBS9362728-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Alternative Oxidase (AOX) ELISA Kit
MBS9362728-48StripWells 48-Strip-Wells
EUR 550

Human Alternative Oxidase (AOX) ELISA Kit
MBS9362728-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Alternative Oxidase (AOX) ELISA Kit
MBS9362728-96StripWells 96-Strip-Wells
EUR 765

Goose Alternative Oxidase (AOX) ELISA Kit
MBS9358234-INQUIRE INQUIRE Ask for price

Horse Alternative Oxidase (AOX) ELISA Kit
MBS9363789-10x96StripWells 10x96-Strip-Wells
EUR 6725

Horse Alternative Oxidase (AOX) ELISA Kit
MBS9363789-48StripWells 48-Strip-Wells
EUR 550

Horse Alternative Oxidase (AOX) ELISA Kit
MBS9363789-5x96StripWells 5x96-Strip-Wells
EUR 3420

Horse Alternative Oxidase (AOX) ELISA Kit
MBS9363789-96StripWells 96-Strip-Wells
EUR 765

Human Alternative Oxidase(ATO) ELISA Kit
NSL1402Hu 96 wells
EUR 468
Description: Sandwich ELISA

Alternative Thioglycollate HiVeg™ Mediu
MV010-2.5KG 1 unit
EUR 80.4
Description: Alternative Thioglycollate HiVeg™ Mediu

Alternative Thioglycollate HiVeg™ Mediu
MV010-5KG 1 unit
EUR 140.79
Description: Alternative Thioglycollate HiVeg™ Mediu

Alternative Thioglycollate HiVeg™ Mediu
MV010G-2.5KG 1 unit
EUR 100.96
Description: Alternative Thioglycollate HiVeg™ Mediu

Alternative Thioglycollate HiVeg™ Mediu
MV010G-500G 1 unit
EUR 22.42
Description: Alternative Thioglycollate HiVeg™ Mediu

Bovine Alternative Oxidase(ATO) ELISA Kit
MBS2610152-10x96StripWells 10x96-Strip-Wells
EUR 3545

Bovine Alternative Oxidase(ATO) ELISA Kit
MBS2610152-48StripWells 48-Strip-Wells
EUR 310

Bovine Alternative Oxidase(ATO) ELISA Kit
MBS2610152-5x96StripWells 5x96-Strip-Wells
EUR 1940

Bovine Alternative Oxidase(ATO) ELISA Kit
MBS2610152-96StripWells 96-Strip-Wells
EUR 475

Canine Alternative Oxidase (ATO) ELISA Kit
MBS2603130-10x96StripWells 10x96-Strip-Wells
EUR 3545

Canine Alternative Oxidase (ATO) ELISA Kit
MBS2603130-48StripWells 48-Strip-Wells
EUR 310

Canine Alternative Oxidase (ATO) ELISA Kit
MBS2603130-5x96StripWells 5x96-Strip-Wells
EUR 1940

Canine Alternative Oxidase (ATO) ELISA Kit
MBS2603130-96StripWells 96-Strip-Wells
EUR 475

Rabbit Alternative Oxidase (ATO) ELISA Kit
MBS2604905-10x96StripWells 10x96-Strip-Wells
EUR 3545

Rabbit Alternative Oxidase (ATO) ELISA Kit
MBS2604905-48StripWells 48-Strip-Wells
EUR 310

Rabbit Alternative Oxidase (ATO) ELISA Kit
MBS2604905-5x96StripWells 5x96-Strip-Wells
EUR 1940

Rabbit Alternative Oxidase (ATO) ELISA Kit
MBS2604905-96StripWells 96-Strip-Wells
EUR 475

Monkey Alternative Oxidase (AOX) ELISA Kit
MBS9369884-10x96StripWells 10x96-Strip-Wells
EUR 6725

Monkey Alternative Oxidase (AOX) ELISA Kit
MBS9369884-48StripWells 48-Strip-Wells
EUR 550

Monkey Alternative Oxidase (AOX) ELISA Kit
MBS9369884-5x96StripWells 5x96-Strip-Wells
EUR 3420

Monkey Alternative Oxidase (AOX) ELISA Kit
MBS9369884-96StripWells 96-Strip-Wells
EUR 765

Donkey Alternative Oxidase (AOX) ELISA Kit
MBS9352546-INQUIRE INQUIRE Ask for price

Rabbit Alternative Oxidase (AOX) ELISA Kit
MBS9368195-INQUIRE INQUIRE Ask for price

Canine Alternative Oxidase (AOX) ELISA Kit
MBS9356716-10x96StripWells 10x96-Strip-Wells
EUR 6725

Canine Alternative Oxidase (AOX) ELISA Kit
MBS9356716-48StripWells 48-Strip-Wells
EUR 550

Canine Alternative Oxidase (AOX) ELISA Kit
MBS9356716-5x96StripWells 5x96-Strip-Wells
EUR 3420

Canine Alternative Oxidase (AOX) ELISA Kit
MBS9356716-96StripWells 96-Strip-Wells
EUR 765

Bovine Alternative Oxidase (AOX) ELISA Kit
MBS9360943-10x96StripWells 10x96-Strip-Wells
EUR 6725

Bovine Alternative Oxidase (AOX) ELISA Kit
MBS9360943-48StripWells 48-Strip-Wells
EUR 550

Bovine Alternative Oxidase (AOX) ELISA Kit
MBS9360943-5x96StripWells 5x96-Strip-Wells
EUR 3420

Bovine Alternative Oxidase (AOX) ELISA Kit
MBS9360943-96StripWells 96-Strip-Wells
EUR 765

Pigeon Alternative Oxidase (AOX) ELISA Kit
MBS9364534-INQUIRE INQUIRE Ask for price

Canine Alternative Oxidase(ATO) ELISA Kit
NSL1846Ca 1941 wells
EUR 528
Description: Sandwich ELISA

Bovine Alternative Oxidase(ATO) ELISA Kit
NSL1886Bo 96 T
EUR 528
Description: Sandwich ELISA

Alternative Thioglycollate HiVeg™ Medium
MV010G-5KG 1 unit
EUR 181.49
Description: Alternative Thioglycollate HiVeg™ Medium

Dog Alternative Splicing Factor ELISA kit
E08A0625-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Alternative Splicing Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Alternative Splicing Factor ELISA kit
E08A0625-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Alternative Splicing Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Alternative Splicing Factor ELISA kit
E08A0625-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Alternative Splicing Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Alternative Splicing Factor ELISA kit
E07A0625-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Alternative Splicing Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Alternative Splicing Factor ELISA kit
E07A0625-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Alternative Splicing Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Alternative Splicing Factor ELISA kit
E07A0625-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Alternative Splicing Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Alternative Splicing Factor ELISA kit
E01A9021 96T
EUR 700
Description: ELISA

Rat Alternative Splicing Factor ELISA kit
E02A0625-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Alternative Splicing Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Alternative Splicing Factor ELISA kit
E02A0625-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Alternative Splicing Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Alternative Splicing Factor ELISA kit
E02A0625-48wellsplate 48 wells plate
EUR 280

Rat Alternative Splicing Factor ELISA kit
E02A0625-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Alternative Splicing Factor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Alternative Splicing Factor ELISA kit
E02A0625-96wellsplate 96 wells plate
EUR 405

Cat Alternative Splicing Factor ELISA Kit
MBS096954-INQUIRE INQUIRE Ask for price

Rat Alternative Splicing Factor ELISA Kit
MBS020334-10x96StripWells 10x96-Strip-Wells
EUR 6725

Rat Alternative Splicing Factor ELISA Kit
MBS020334-48StripWells 48-Strip-Wells
EUR 550

Rat Alternative Splicing Factor ELISA Kit
MBS020334-5x96StripWells 5x96-Strip-Wells
EUR 3420

Rat Alternative Splicing Factor ELISA Kit
MBS020334-96StripWells 96-Strip-Wells
EUR 765

Chicken Alternative Oxidase (ATO) ELISA Kit
MBS2608145-10x96StripWells 10x96-Strip-Wells
EUR 3545

Chicken Alternative Oxidase (ATO) ELISA Kit
MBS2608145-48StripWells 48-Strip-Wells
EUR 310

Chicken Alternative Oxidase (ATO) ELISA Kit
MBS2608145-5x96StripWells 5x96-Strip-Wells
EUR 1940

Chicken Alternative Oxidase (ATO) ELISA Kit
MBS2608145-96StripWells 96-Strip-Wells
EUR 475

Porcine Alternative Oxidase (ATO) ELISA Kit
MBS2608462-10x96StripWells 10x96-Strip-Wells
EUR 3545

Porcine Alternative Oxidase (ATO) ELISA Kit
MBS2608462-48StripWells 48-Strip-Wells
EUR 310

Porcine Alternative Oxidase (ATO) ELISA Kit
MBS2608462-5x96StripWells 5x96-Strip-Wells
EUR 1940

Porcine Alternative Oxidase (ATO) ELISA Kit
MBS2608462-96StripWells 96-Strip-Wells
EUR 475

Rat Alternative Splicing Factor ELISA Kit
MBS730200-10x96StripWells 10x96-Strip-Wells
EUR 5685

Rat Alternative Splicing Factor ELISA Kit
MBS730200-48StripWells 48-Strip-Wells
EUR 485

Rat Alternative Splicing Factor ELISA Kit
MBS730200-5x96StripWells 5x96-Strip-Wells
EUR 3020

Rat Alternative Splicing Factor ELISA Kit
MBS730200-96StripWells 96-Strip-Wells
EUR 690

Chicken Alternative Oxidase (AOX) ELISA Kit
MBS9356224-INQUIRE INQUIRE Ask for price
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