Regulation of Host Immune Responses against Influenza A Virus Infection by Mitogen-Activated Protein Kinases (MAPKs)

Influenza is a major respiratory viral illness caused by infection of influenza A virus (IAV), which still persists in various global seasonal epidemics every year. the host immune response is a key factor that determines the severity of influenza infection, present an attractive target for the development of new therapies for the treatment.

Among the double track signal transduction that regulates the activation of the host immune response and function in response to infection IAV, the mitogen-activated protein kinase (MAPK) pathway that wicks important signaling, downstream receptors pattern recognition (PRRS), activated by IAVs that regulate various processes cell in the immune cells of both the innate and adaptive immunity.

In addition, aberrant activation of MAPK overexuberant underlying the production of inflammatory mediators, promoting the development of a “cytokine storm”, the characteristics of severe respiratory viral diseases. Therefore, explanation of MAPK regulatory role in the immune response to IAVs not only important for understanding the pathogenesis of severe influenza, but it is also important to develop a MAPK-dependent therapies for the treatment of respiratory viral diseases. In this review, we will summarize the current understanding of the function of MAPK in both the innate and adaptive immune responses to IAVs and discuss their contribution to the cytokine storm caused by the highly pathogenic influenza virus.


Trimeric soluble recombinant influenza A virus hemagglutinins (HA) and tetrameric neuraminidases (NA) has proven to be an excellent tool to decipher biological properties. Receptor binding and cleavage of sialic acid by a recombinant protein correlated satisfactory compared with the whole virus. Expression of HA and NA can be achieved in many different laboratories host.

For the study of immunology and receptor interactions, however, insect and mammalian cell expressed proteins are preferred because of the presence of N-linked glycosylation and disulfide bond formation. Because the expression of mammalian cells is widely applied, yield enhancement expression is an important goal. Here we report that the use of codon-optimized genes and fusion sfGFP, HA expression results can be improved

Regulation of Host Immune Responses against Influenza A Virus Infection by Mitogen-Activated Protein Kinases (MAPKs)
Regulation of Host Immune Responses against Influenza A Virus Infection by Mitogen-Activated Protein Kinases (MAPKs)

Comparative Analysis of Antiviral Activity of IgG and IgA antibodies to Influenza A Virus M2 Protein

The influenza A virus (IAV) matrix-2 (M2) protein is a viral envelope proteins conserved antigens that plays an important role in virus starters together with other envelope proteins, hemagglutinin (HA). M2-specific mouse monoclonal antibody IgG, rM2ss23, which binds to the ectodomain of the M2 protein, has been shown to be non-neutralizing antibodies, but inhibits plaque formation IAV strains.

In this study, we produce rM2ss23 chimeric (ch-rM2ss23) IgG and IgA antibodies with the same variable region and compared their antiviral activity. Using gel chromatography, ch-rM2ss23 IgA is divided into three subsets of antibodies: IgA monomer (m-IgA), dimeric IgA (d-IgA), and trimeric and tetrameric IgA (t / q-IgA).

Streptavidin-HRP (For PARP & Cytokine Assay Kits)

80611 100 µl
EUR 100
Description: Streptavidin-HRP is useful in select BPS Bioscience assay kits.

Blocking Buffer 1 (Various Epigenetics Assay Kits)

79556 50 ml
EUR 100
Description: This Blocking Buffer 1 is optimized for minimizing background in various BPS Bioscience assay kits. The BPS Bioscience Blocking Buffer improves S/B ratio of HMTs NSD2 and SetDB2 ELISAs with respect to competitor blocking buffer by both decreasing background (0% Activity control, no enzyme) and increasing assay signal (100% Activity control, enzyme without inhibitor).

Blocking Buffer 4 (Multiple Epigenetics Assay Kits)

52100 50 ml
EUR 95
Description: This Blocking Buffer 4 is optimized for minimizing background in various chemiluminescent methyltransferase, demethylase, and TET assays.

Assay kit

SL1999Hu 96 Tests
EUR 468

EdU Imaging Kits (488)

K1175-50 50-500 tests
EUR 240
Description: EdU Imaging Kits (488) is a sensitive and reliable way to detect and quantify cell proliferation in cells. It is optimized for fluorescence microscopy. It is a better alternative to traditional BrdU (bromodeoxyuridine).

BSA Standard kits

TBS5002 7x 1ml
EUR 45

DNA Assay Kit

6023 1 kit
EUR 113
Description: Tissue Extract, Cultured Cells

ROS Assay Kit

EGY019 100-500T
EUR 192

PDE Assay Kit

GWB-58EAA2 96reactions Ask for price

SYK Assay Kit

79671 96 rxns.
EUR 525
Description: SYK of the nonreceptor tyrosine kinases plays a role in autoimmune diseases like Epstein Barr virus and hematopoietic malignancies. The SYK Assay Kit is designed to measure SYK activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.

SRC Assay Kit

79680 96 rxns.
EUR 535
Description: SRC is a member of the nonreceptor tyrosine kinases that plays a role in many cellular functions, including cell adhesion, growth, and differentiation. SRC has been implicated in diseases such as chronic kidney disease and metastatic bone disease. The SRC Assay Kit is designed to measure SRC activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The SRC Assay Kit comes in a convenient 96-well format, with enough purified recombinant SRC enzyme, Protein Tyrosine Kinase Substrate (Poly-Glu,Tyr 4:1), ATP, and kinase assay buffer for 100 enzyme reactions.

LCK Assay Kit

79794 96 rxns.
EUR 535
Description: The LCK Assay Kit is designed to measure LCK activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.

POP Assay Kit

80106 96 rxns.
EUR 685
Description: The Fluorogenic Prolyl OligoPeptidase (POP)_x000D_ Assay Kit is a complete assay system designed to measure activity of the purified POP_x000D_ enzyme. The Fluorogenic POP Activity Kit eliminates the dealing with radioactive_x000D_ materials and chromatography in traditional assays. Purified human recombinant POP is_x000D_ included in the kit as a positive control. Using this kit, only one simple step, in which the_x000D_ fluorometric substrate is incubated with purified POP, is needed to analyze the POP_x000D_activity level. The resulting fluorescent product can then be easily measured with a_x000D_ microtiter-plate fluorimeter.

FAP Assay Kit

80210 96 rxns.
EUR 1175
Description: The Fluorogenic FAP Assay Kit is designed to measure FAP activity using purified_x000D_FAP for screening and profiling applications. _x000D_The key to the Fluorogenic FAP Assay Kit is the fluorogenic substrate. Using this kit,_x000D_only one simple step on a microtiter plate is required for FAP reactions. The DPP_x000D_fluorometric substrate is incubated with a sample containing FAP enzyme to produce a_x000D_fluorophore that can then be measured using a fluorescence reader.

HAT Assay Kit

55R-1373 100 assays
EUR 600
Description: Assay Kit for detection of HAT in the research laboratory

SOD Assay Kit

55R-1374 100 assays
EUR 480
Description: Assay Kit for detection of SOD in the research laboratory

ATP Assay Kit

55R-1380 100 assays
EUR 653
Description: Assay Kit for detection of ATP in the research laboratory

ADP Assay Kit

55R-1381 100 assays
EUR 633
Description: Assay Kit for detection of ADP in the research laboratory

FAD Assay Kit

55R-1382 100 assays
EUR 567
Description: Assay Kit for detection of FAD in the research laboratory

PEP Assay Kit

55R-1384 100 assays
EUR 687
Description: Assay Kit for detection of PEP in the research laboratory

JNK Assay Kit

55R-1407 40 assays
EUR 667
Description: Assay Kit for detection of JNK in the research laboratory

JNK Assay Kit

55R-1408 40 assays
EUR 753
Description: Assay Kit for detection of JNK in the research laboratory

Akt Assay Kit

55R-1409 40 assays
EUR 773
Description: Assay Kit for detection of Akt in the research laboratory

MDA Assay Kit

55R-1512 100 assays
EUR 653
Description: Assay Kit for detection of MDA in the research laboratory

PAH Assay Kit

55R-1547 100 assays
EUR 593
Description: Assay Kit for detection of PAH in the research laboratory

FYN Assay Kit

78003 96 rxns.
EUR 535
Description: The FYN Assay Kit is designed to measure FYN activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.

RET Assay Kit

79566 96 rxns.
EUR 535
Description: RET is a receptor kinase for GDNF (glial cell-line derived neurotrophic factor) family ligands (GFLs). Activation of wild-type RET is important in several cancers where it contributes to tumor progression through various mechanisms. In addition, it has been shown that activating mutation as well as RET rearrangement that leads constitutively active protein plays a significant role in various cancer types. Importantly, small molecule inhibitors of RET have been clinically proved as a promising therapeutic reagent in medullary thyroid cancer and are being evaluated for other types of cancers related to RET overexpression or mutation. The RET Assay Kit is designed to measure RET activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The RET Assay Kit comes in a convenient 96-well format, with enough purified recombinant RET enzyme, RET substrate peptide (IRF-1Rtide), ATP and kinase assay buffer for 100 enzyme reactions.

BTK Assay Kit

79568 96 rxns.
EUR 560
Description: Bruton's tyrosine kinase or BTK, is an enzyme that plays a role in the functionality and maturation of B cells. The BTK pathway has implications for a number of autoimmune disorders including isolated growth hormone deficiency type III and rheumatoid arthritis. The BTK Assay Kit is designed to measure BTK activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The BTK Assay Kit comes in a convenient 96-well format, with enough purified recombinant BTK enzyme, PolyGluTyr peptide, ATP, and kinase assay buffer for 100 enzyme reactions.

ADA Assay Kit

abx098403-Hitachi7060R190ml2R290ml1 Hitachi 7060; R1: 90ml×2 R2: 90ml×1
EUR 886.8

ADA Assay Kit

abx098403-Hitachi7170R140ml4R220ml4 Hitachi 7170; R1: 40ml×4 R2: 20ml×4
EUR 961.2

ADA Assay Kit

abx098403-Hitachi7170R160ml4R260ml2 Hitachi 7170; R1: 60ml×4 R2: 60ml×2
EUR 1093.2

ADA Assay Kit

abx098403-Toshiba40R150ml4R250ml2 Toshiba 40; R1: 50ml×4 R2: 50ml×2
EUR 943.2

ADA Assay Kit

abx090675-100tests 100 tests
EUR 284.4

FAD Assay Kit

GWB-AXR210 100 assays Ask for price

POP assay kit

GWB-911136 100reactions Ask for price

FAP assay kit

GWB-BBB243 100reactions Ask for price

GAP Assay Kit

BK105 KIT 80-160 assays
EUR 769.6

DNA Assay Kit

Z5030023 250 assays
EUR 636

ATP Assay Kit

Z5030041 100 assays
EUR 922

H2S Assay Kit

abx294158-100g 100 µg Ask for price

H2S Assay Kit

abx294158-20g 20 µg
EUR 287.5

H2S Assay Kit

abx294158-50g 50 µg Ask for price

ATP Assay Kit

abx295077-100g 100 µg Ask for price

ATP Assay Kit

abx295077-20g 20 µg
EUR 475

ATP Assay Kit

abx295077-50g 50 µg Ask for price

DPP3 assay kit

GWB-24385A 100reactions Ask for price

DPP8 assay kit

GWB-53E1CE 100reactions Ask for price

DPP4 assay kit

GWB-380197 100reactions Ask for price

DPP7 assay kit

GWB-3C2D94 100reactions Ask for price

Iron Assay Kit

abx298872-100Assays 100 Assays
EUR 510

Zinc Assay Kit

abx298876-100Assays 100 Assays
EUR 698.4

CDK9 Assay Kit

79628 96 rxns.
EUR 575
Description: Cyclin-dependent kinase 9 (CDK9) is the catalytic subunit of the positive transcription elongation factor b (P-TEFb), which phosphorylates the C-terminal domain of RNA polymerase II, a key player in the production of mature RNA. The CDK9 Assay Kit is designed to measure CDK9/CyclinT activity for screening and profiling applications, using Kinase-Glo® MAX as a detection reagent. The CDK9 Assay Kit comes in a convenient 96-well format, with enough purified recombinant CDK9/CyclinT enzyme, CDK substrate peptide 2, ATP and kinase assay buffer for 100 enzyme reactions.

CDK4 Assay Kit

79674 96 rxns.
EUR 550
Description: Cyclin-dependent kinase 4 (CDK4) assembles with the "D" type of Cyclins, e.g. cyclins D1, D2, and D3, and play a pivotal role in the cell cycle entering the S phase. Dysregulation of the activity of CDK4 is related to many different cancers, indicating CDK4 inhibitors as promising anticancer treatments. In fact, multiple CDK4 inhibitors, including Palbociclib, were approved by the FDA recently. The CDK4 Assay Kit is designed to measure CDK4/CyclinD3 activity for screening and profiling applications, using Kinase-Glo® Max as a detection reagent.

YES1 Assay Kit

79681 96 rxns.
EUR 535
Description: Proto-oncogene tyrosine-protein kinase YES1 has been implicated in regulation of cell growth and survival, apoptosis, cell-cell adhesion, and differentiation. It has been identified as a potential target in basal-like breast cancers. The YES1 Assay Kit is designed to measure YES1 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The YES1 Assay Kit comes in a convenient 96-well format, with enough purified recombinant YES1 enzyme, Protein Tyrosine Kinase Substrate (Poly-Glu,Tyr 4:1), ATP, and kinase assay buffer for 100 enzyme reactions.

HPK1 Assay Kit

79775 96 rxns.
EUR 560
Description: The HPK1 Assay Kit is designed to measure HPK1 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.

cKIT Assay Kit

79815 96 rxns.
EUR 535
Description: The cKIT Assay Kit is designed to measure cKIT activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent.

TBK1 Assay Kit

79871 96 rxns.
EUR 510
Description: The TBK1 Assay Kit is designed to measure TBK1 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.

PIM2 Assay Kit

79883 96 rxns.
EUR 535
Description: The PIM2 Assay Kit is designed to measure PIM2 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. 

PIM1 Assay Kit

79885 96 rxns.
EUR 560
Description: The PIM1 Assay Kit is designed to measure PIM1 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. 

PIM3 Assay Kit

79886 96 rxns.
EUR 535
Description: The PIM3 Assay Kit is designed to measure PIM3 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. 

ACLY Assay Kit

79904 96 rxns.
EUR 590
Description: ATP citrate lyase (ACLY) is an important enzyme in fatty acid synthesis and cancer metabolism. The ACLY Assay Kit is designed to measure ACLY activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent. 

Wee1 Assay Kit

79909 96 rxns.
EUR 560
Description: The Wee1 Assay Kit is designed to measure Wee1 activity for screening and profiling applications using Kinase-Glo® Kinase Assay as a detection reagent. 

DPP4 Assay Kit

80204 96 rxns.
EUR 465
Description: The Fluorogenic DPP4 Assay Kit is_x000D_designed to measure DPP4 activity using purified DPP4 for screening and profiling applications._x000D_ The key to the Fluorogenic DPP4 Assay Kit_x000D_is the specific, fluorogenic substrate. Using this kit, only one simple step on a microtiter_x000D_plate is required for DPP4 reactions; no time-consuming washing steps are required. The DPP fluorometric substrate is incubated with a_x000D_sample containing DPP4 enzyme to produce a fluorophore that can then be measured_x000D_using a fluorescence reader._x000D_

DPP7 Assay Kit

80207 96 rxns.
EUR 515
Description: The Fluorogenic DPP7 Assay Kit is_x000D_designed to measure DPP7 activity using purified DPP7 for screening and profiling applications._x000D_The key to the Fluorogenic DPP7 Assay Kit is the_x000D_specific, fluorogenic substrate. Using this kit, only one simple step on a microtiter plate is_x000D_required for DPP7 reactions. The fluorometric substrate is incubated with a sample_x000D_containing DPP7 enzyme to produce a fluorophore that can then be measured using a_x000D_fluorescence reader.

DPP8 Assay Kit

80208 96 rxns.
EUR 515
Description: The Fluorogenic DPP8_x000D_Assay Kit is designed to measure DPP8 activity using purified DPP8 for screening and_x000D_profiling applications. The key to_x000D_the Fluorogenic DPP8 Assay Kit is the fluorogenic substrate. Using this kit, only one_x000D_simple step on a microtiter plate is required for DPP8 reactions. The fluorometric_x000D_substrate is incubated with a sample containing DPP8 enzyme to produce a fluorophore_x000D_that can then be measured using a fluorescence reader._x000D_

HDAC Assay Kit

55R-1371 100 assays
EUR 540
Description: Assay Kit for detection of HDAC in the research laboratory

HDAC Assay Kit

55R-1372 100 assays
EUR 540
Description: Assay Kit for detection of HDAC in the research laboratory

cAMP Assay Kit

55R-1389 100 assays
EUR 567
Description: Assay Kit for detection of cAMP activity in the research laboratory

cGMP Assay Kit

55R-1390 100 assays
EUR 567
Description: Assay Kit for detection of cGMP activity in the research laboratory

Urea Assay Kit

55R-1391 100 assays
EUR 600
Description: Assay Kit for detection of Urea in the research laboratory

Zinc Assay Kit

55R-1394 100 assays
EUR 540
Description: Assay Kit for detection of Zinc in the research laboratory

Iron Assay Kit

55R-1395 100 assays
EUR 613
Description: Assay Kit for detection of Iron in the research laboratory

Heme Assay Kit

55R-1492 100 assays
EUR 540
Description: Assay Kit for detection of Heme in the research laboratory

DPP4 Assay Kit

55R-1526 100 assays
EUR 593
Description: Assay Kit for detection of DPP4 in the research laboratory

MMP3 Assay Kit

55R-1530 100 assays
EUR 567
Description: Assay Kit for detection of MMP3 in the research laboratory

HER4 Assay Kit

78005 96 rxns.
EUR 535
Description: The HER4 Assay Kit is designed to measure HER4 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. 

AKT1 Assay Kit

78038 96 rxns.
EUR 535
Description: The AKT1 Assay Kit is designed to measure AKT1 activity for screening and profiling applications using Kinase-Glo® Kinase Assay as a detection reagent. 

TrkA Assay Kit

79548 96 rxns.
EUR 535
Description: The tropomyosin receptor kinases (TRK) are a family of tyrosine receptor kinases, which include TrkA, TrkB and TrkC. TrkA is activated by binding to nerve growth factor (NGF), resulting in activation of cell proliferation through the RAS/MAPK/ERK and PLCγ/PI3K pathways. Constitutive activation of TrkA is associated with colorectal cancer, suggesting TrkA inhibitors may have potential therapeutic value. The TrkA Assay Kit is designed to measure TrkA activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The TrkA Assay Kit comes in a convenient 96-well format, with enough purified recombinant TrkA enzyme, TrkA substrate, ATP and kinase assay buffer for 100 enzyme reactions.

CDK1 Assay Kit

79597 96 rxns.
EUR 535
Description: Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. CDKs are active only when bound to their regulator proteins, cyclins. CDK activity is tightly controlled for successful cell division. Since abnormal cell division represents cancer pathology, controlling CDK activity has been shown as a promising therapeutic strategy. In particular, CDK1 plays an important role in mitotic progression. The CDK1 Assay Kit is designed to measure CDK1/CyclinB1 activity for screening and profiling applications, using Kinase-Glo® MAX as a detection reagent.

CDK2 Assay Kit

79599 96 rxns.
EUR 535
Description: Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. CDKs are active only when bound to their regulator proteins, cyclins. CDK activity is tightly controlled for successful cell division. Since abnormal cell division represents cancer pathology, controlling CDK activity has been shown as a promising therapeutic strategy. In particular, CDK2 plays an important role in DNA replication. The CDK2 Assay Kit is designed to measure CDK2/CyclinA2 activity for screening and profiling applications, using Kinase-Glo® MAX as a detection reagent.

CDK5 Assay Kit

79600 96 rxns.
EUR 535
Description: CDK5 is an unconventional member of the CDK family. It is expressed in post-mitotic neurons, and its activity is regulated by neuron-specific activators p35/p25 and p39 rather than the cyclins. It has been suggested that CDK5 plays several roles in the nervous system, including Tau aggregation and tangle formation. The CDK5 Assay Kit is designed to measure CDK5 activity for screening and profiling applications, using Kinase-Glo® MAX as a detection reagent.

CDK7 Assay Kit

79603 96 rxns.
EUR 535
Description: Cyclin-dependent kinase 7 (CDK7) assembled with Cyclin H and MAT1 comprises an important sub-component of the transcription factor TFIIH. It is known to have dual roles, which include transcription regulation via phosphorylating the C-terminal domain (CTD) of RNA polymerase II as well as controlling cell cycle progression as a CDK activating kinase (CAK). The CDK7 Assay Kit is designed to measure CDK7/Cyclin H/MAT1 activity for screening and profiling applications, using ADP-Glo® as a detection reagent.

Iron Assay Kit

abx098439-Hitachi7020R140ml1R210ml1 Hitachi 7020; R1:40ml×1 R2:10ml×1
EUR 247.2

Iron Assay Kit

abx098439-Hitachi7170R140ml1R210ml1 Hitachi 7170; R1:40ml×1 R2:10ml×1
EUR 247.2

Iron Assay Kit

abx098439-Hitachi7170R160ml1R215ml1 Hitachi 7170; R1:60ml×1 R2:15ml×1
EUR 266.4

Iron Assay Kit

abx098439-Toshiba40R140ml1R210ml1 Toshiba 40; R1:40ml×1 R2:10ml×1
EUR 247.2

NGAL Assay Kit

abx098449-Hitachi7020R140ml1R210ml1 Hitachi 7020; R1: 40ml×1 R2: 10ml×1
EUR 1130.4

NGAL Assay Kit

abx098449-Hitachi7170R120ml1R25ml1 Hitachi 7170; R1: 20ml×1 R2: 5ml×1
EUR 679.2

NGAL Assay Kit

abx098449-Hitachi7170R140ml1R210ml1 Hitachi 7170; R1: 40ml×1 R2: 10ml×1
EUR 1130.4

NGAL Assay Kit

abx098449-Toshiba120R140ml1R210ml1 Toshiba 120; R1: 40ml×1 R2: 10ml×1
EUR 1130.4

NGAL Assay Kit

abx098449-Toshiba40R140ml1R210ml1 Toshiba 40; R1: 40ml×1 R2: 10ml×1
EUR 1130.4

Urea Assay Kit

abx098464-Hitachi7020R150ml4R250ml1 Hitachi 7020; R1: 50ml×4 R2: 50ml×1
EUR 266.4

Urea Assay Kit

abx098464-Hitachi7060R190ml2R245ml1 Hitachi 7060; R1: 90ml×2 R2: 45ml×1
EUR 266.4

Urea Assay Kit

abx098464-Toshiba120R140ml4R240ml1 Toshiba 120; R1: 40ml×4 R2: 40ml×1
EUR 266.4

AMBP Assay Kit

abx098467-Hitachi7060R145ml1R215ml1 Hitachi 7060; R1: 45ml×1 R2: 15ml×1
EUR 585.6

AMBP Assay Kit

abx098467-Hitachi7060R190ml2R230ml2 Hitachi 7060; R1: 90ml×2 R2: 30ml×2
EUR 622.8

AMBP Assay Kit

abx098467-Hitachi7170R145ml1R215ml1 Hitachi 7170; R1: 45ml×1 R2: 15ml×1
EUR 585.6

AMBP Assay Kit

abx098467-Toshiba40R145ml1R215ml1 Toshiba 40; R1: 45ml×1 R2: 15ml×1
EUR 585.6

Urea Assay Kit

GWB-AXR219 100 assays Ask for price

Zinc Assay Kit

GWB-AXR222 100 assays Ask for price

Iron Assay Kit

GWB-AXR223 100 assays Ask for price

Heme Assay Kit

GWB-AXR320 100 assays Ask for price

Urea Assay Kit

STA-382 192 assays
EUR 565

DPP9 assay kit

GWB-67DE80 100reactions Ask for price

GPDH Assay Kit

KT-010 100 tests
EUR 1223

Urea Assay Kit

Z5030016 500 assays
EUR 670

Iron Assay Kit

Z5030022 250 assays
EUR 668

Heme Assay Kit

Z5030027 250 assays
EUR 1072

Zinc Assay Kit

Z5030036 250 assays
EUR 1106

Iron Assay Kit

abx294097-100g 100 µg Ask for price

Iron Assay Kit

abx294097-20g 20 µg
EUR 287.5

Iron Assay Kit

abx294097-50g 50 µg Ask for price

Iron Assay Kit

abx298872-100g 100 µg Ask for price

Iron Assay Kit

abx298872-20g 20 µg
EUR 300

Iron Assay Kit

abx298872-50g 50 µg Ask for price

Zinc Assay Kit

abx298876-100g 100 µg Ask for price

Zinc Assay Kit

abx298876-20g 20 µg
EUR 425

Zinc Assay Kit

abx298876-50g 50 µg Ask for price

PDE1A Assay Kit

60310 96 rxns.
EUR 405
Description: The PDE1A Assay Kit is designed for identification of PDE1A inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE1A1 to the binding agent. The key to the PDE1A Assay Kit is the specific binding agent. Using this kit, only two simple steps on a microtiter plate are required for PDE1A reactions. First, the fluorescently labeled cAMP is incubated with a sample containing PDE1A1 for 1 hour. Second, a binding agent is added to the reaction mix to produce a change in fluorescent polarization that can then be measured using a fluorescence reader._x000D_

PDE1B Assay Kit

60311 96 rxns.
EUR 405
Description: The PDE1B Assay Kit is designed for identification of PDE1B inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE1B to the binding agent. The key to the PDE1B Assay Kit is the specific binding agent. Using this kit, only two simple steps on a microtiter plate are required for PDE1B reactions. First, the fluorescently labeled cAMP is incubated with a sample containing PDE1B for 1 hour. Second, a binding agent is_x000D_added to the reaction mix to produce a change in fluorescent polarization that can then be_x000D_measured using a fluorescence reader equipped for the measurement of fluorescence_x000D_polarization.

PDE1C Assay Kit

60312 96 rxns.
EUR 405
Description: The PDE1C Assay Kit is designed for identification of PDE1C inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE1C to the binding agent. The key to the PDE1C Assay Kit is the_x000D_specific binding agent. Using this kit, only two simple steps on a microtiter plate are_x000D_required for PDE1C reactions. First, the fluorescently labeled cAMP is incubated with a_x000D_sample containing PDE1C for 1 hour. Second, a binding agent is added to the reaction_x000D_mix to produce a change in fluorescent polarization that can then be measured using a_x000D_fluorescence reader.

PDE2A Assay Kit

60320 96 rxns.
EUR 405
Description: The PDE2A Assay Kit is_x000D_designed for identification of PDE2A1 inhibitors using fluorescence polarization. The_x000D_assay is based on the binding of a fluorescent nucleotide monophosphate generated by_x000D_PDE2A1 to the binding agent. The key to the PDE2A Assay Kit is the_x000D_specific binding agent. Using this kit, only two simple steps on a microtiter plate are_x000D_required for PDE2A1 reactions. First, the fluorescently labeled cAMP is incubated with a_x000D_sample containing PDE2A1 for 1 hour. Second, binding agent is added to the reaction mix to_x000D_produce a change in fluorescent polarization that can then be measured using a_x000D_fluorescence readerequipped for the measurement of fluorescence polarization._x000D_

PDE2A Assay Kit

60321 384 rxns.
EUR 800
Description: The PDE2A Assay Kit is designed for identification of PDE2A inhibitors using_x000D_fluorescence polarization.The assay is based on the binding of a fluorescent nucleotide_x000D_monophosphate generated by PDE2A to the binding agent. PDE2A catalyzes the hydrolysis of_x000D_the phosphodiester bond in dye-labeled cyclic adenosine monophosphate (cAMP)._x000D_Nanoparticle beads selectively bind the phosphate group in the nucleotide product. This_x000D_increases the size of the nucleotide relative to unreacted cAMP. Since the degree of polarization_x000D_of a fluorophore is inversely related to its molecular rotation, dyes attached to the slowly-rotating_x000D_nucleotide-bead complexes will not have time to reorient and therefore will emit highly polarized_x000D_light. Conversely, dyes attached to the rapidly-rotating cyclic monophosphates will obtain_x000D_random orientations and emit light with low polarization. The key to the PDE2A Assay Kit is the specific_x000D_binding agent. Using this kit, only two simple steps on a microtiter plate are required for PDE2A_x000D_reactions. First, the fluorescently labeled cAMP is incubated with a sample containing PDE2A1_x000D_for 1 hour. Second, a binding agent is added to the reaction mix to produce a change in_x000D_fluorescent polarization that can then be measured using a fluorescence reader.

PDE3B Assay Kit

60331 96 rxns.
EUR 425
Description: The PDE3B Assay Kit is designed for identification of PDE3B inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE3B to the binding agent. The key to the PDE3B Assay Kit is the_x000D_specific binding agent. Using this kit, only two simple steps on a microtiter plate are_x000D_required for PDE3B reactions. First, the fluorescently labeled cAMP is incubated with a_x000D_sample containing PDE3B for 1 hour. Second, binding agent is added to the reaction mix to_x000D_produce a change in fluorescent polarization that can then be measured using a_x000D_fluorescence reader equipped for the measurement of fluorescence polarization.

PDE4A Assay Kit

60340 96 rxns.
EUR 425
Description: The PDE4A Assay Kit is designed for identification of PDE4A inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE4A to the binding agent. The key to the_x000D_PDE4A1A Assay Kit is the specific binding agent. Using this kit, only two simple steps on_x000D_a microtiter plate are required for PDE4A1A reactions. First, the fluorescently labeled_x000D_cAMP is incubated with a sample containing PDE4A1A for 1 hour. Second, a binding_x000D_agent is added to the reaction mix to produce a change in fluorescent polarization that_x000D_can then be measured using a fluorescence reader equipped for the measurement of_x000D_fluorescence polarization.

PDE7A Assay Kit

60370 96 rxns.
EUR 405
Description: The PDE7A Assay Kit is designed_x000D_for identification of PDE7A inhibitors using fluorescence polarization. The assay is_x000D_based on the binding of a fluorescent nucleotide monophosphate generated by PDE7A_x000D_to the binding agent. The key to the PDE7A_x000D_Assay Kit is the specific binding agent. Using this kit, only two simple steps on a_x000D_microtiter plate are required for PDE7A reactions. First, the fluorescently labeled cAMP_x000D_is incubated with a sample containing PDE7A for 1 hour. Second, a binding agent is_x000D_added to the reaction mix to produce a change in fluorescent polarization that can then_x000D_be measured using a fluorescence reader.

PDE7B Assay Kit

60371 96 rxns.
EUR 405
Description: The PDE7B Assay Kit is designed for identification of PDE7B inhibitors using fluorescence_x000D_polarization. The assay is based on the binding of a fluorescent nucleotide_x000D_monophosphate generated by PDE7B to the binding agent. The key to the PDE7B Assay Kit is the_x000D_specific binding agent. Using this kit, only two simple steps on a microtiter plate are_x000D_required for PDE7B reactions. First, the fluorescently labeled cAMP is incubated with a_x000D_sample containing PDE7B for 1 hour. Second, a binding agent is added to the reaction_x000D_mix to produce a change in fluorescent polarization that can then be measured using a_x000D_fluorescence reader.

PDE7A Assay Kit

60373 384 rxns.
EUR 800
Description: The PDE7A Assay Kit is designed for identification of PDE7A inhibitors using_x000D_fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide_x000D_monophosphate generated by PDE7A to the binding agent. PDE7A catalyzes the hydrolysis of_x000D_the phosphodiester bond in dye-labeled cyclic adenosine monophosphate (cAMP)._x000D_Nanoparticle beads selectively bind the phosphate group in the nucleotide product. This_x000D_increases the size of the nucleotide relative to unreacted cAMP. Since the degree of polarization_x000D_of a fluorophore is inversely related to its molecular rotation, dyes attached to the slowly-rotating_x000D_nucleotide-bead complexes will not have time to reorient and therefore will emit highly polarized_x000D_light. Conversely, dyes attached to the rapidly-rotating cyclic monophosphates will obtain_x000D_random orientations and emit light with low polarization. The key to the PDE7A Assay Kit is the specific_x000D_binding agent. Using this kit, only two simple steps on a microtiter plate are required for PDE7A_x000D_reactions. First, the fluorescently labeled cAMP is incubated with a sample containing PDE7A_x000D_for 1 hour. Second, a binding agent is added to the reaction mix to produce a change in_x000D_fluorescent polarization that can then be measured using a fluorescence reader.

PDE8A Assay Kit

60380 96 rxns.
EUR 405
Description: The PDE8A Assay Kit is designed for identification of PDE8A inhibitors_x000D_using fluorescence polarization. The assay is based on the binding of a fluorescent_x000D_nucleotide monophosphate generated by PDE8A to the binding agent. The key to the PDE8A_x000D_Assay Kit is the specific binding agent. Using this kit, only two simple steps on a_x000D_microtiter plate are required for PDE8A reactions. First, the fluorescently labeled cAMP_x000D_is incubated with a sample containing PDE8A for 1 hour. Second, a binding agent is_x000D_added to the reaction mix to produce a change in fluorescent polarization that can then_x000D_be measured using a fluorescence reader.

PDE9A Assay Kit

60381 96 rxns.
EUR 405
Description: The PDE9A_x000D_Assay Kit is designed for identification of PDE9A inhibitors using fluorescence_x000D_polarization. The assay is based on the binding of a fluorescent nucleotide_x000D_monophosphate generated by PDE9A to the binding agent. The key to the PDE9A Assay Kit is the_x000D_specific binding agent. Using this kit, only two simple steps on a microtiter plate are_x000D_required for PDE9A reactions. First, the fluorescently labeled cGMP is incubated with a_x000D_sample containing PDE9A for 1 hour. Second, a binding agent is added to the reaction_x000D_mix to produce a change in fluorescent polarization that can then be measured using a_x000D_fluorescence reader._x000D_

PDE1C Assay Kit

60382 384 rxns.
EUR 800
Description: The PDE1C Assay Kit is designed for identification of PDE1C inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE1C to the binding agent. The key to the PDE1C Assay Kit is the specific binding agent. Using this kit, only two simple steps on a microtiter plate are required for PDE1C reactions. First, the fluorescently labeled cAMP is incubated with a sample containing PDE1C for 1 hour. Second, a binding agent is added to the reaction mix to produce a change in fluorescent polarization that can then be measured using a fluorescence reader.

PDE3B Assay Kit

60383 384 rxns.
EUR 800
Description: The PDE3B Assay Kit is designed for identification of PDE3B inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE3B to the binding agent. The key to the PDE3B Assay Kit is the specific binding agent. Using this kit, only two simple steps on a microtiter plate are required for PDE3B reactions. First, the fluorescently labeled cAMP is incubated with a sample containing PDE3B for 1 hour. Second, binding agent is added to the reaction mix to produce a change in fluorescent polarization that can then be measured using a fluorescence reader equipped for the measurement of fluorescence polarization.

PDE4C Assay Kit

60384 384 rxns.
EUR 800
Description: The PDE4C1 Assay Kit is designed for identification of PDE4C1 inhibitors_x000D_using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide_x000D_monophosphate generated by PDE4C1 to the binding agent. The key to the PDE4C1 Assay Kit is the specific_x000D_binding agent. Using this kit, only two simple steps on a microtiter plate are required for_x000D_PDE4C1 reactions. First, the fluorescently labeled cAMP is incubated with a sample containing_x000D_PDE4C1 for 1 hour. Second, a binding agent is added to the reaction mix to produce a change_x000D_in fluorescent polarization that can then be measured using a fluorescence reader.

GSK3α Assay Kit

79698 96 rxns.
EUR 535
Description: The GSK3α Assay Kit is designed to measure GSK3α activity for screening and profiling applications using Kinase-Glo® (Promega) as a detection reagent.

GSK3β Assay Kit

79700 96 rxns.
EUR 590
Description: The GSK3β Assay Kit is designed to measure GSK3β activity for screening and profiling applications using Kinase-Glo® (Promega) as a detection reagent.

PDE3A Assay Kit

79736 96 rxns.
EUR 425
Description: The PDE3A Assay Kit is designed for identification of PDE3A inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE3A to the binding agent. REPLACES #60330

FGFR2 Assay Kit

79804 96 rxns.
EUR 535
Description: The FGFR2 Assay Kit is designed to measure FGFR2 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.

FGFR4 Assay Kit

79807 96 rxns.
EUR 535
Description: The FGFR4 Assay Kit is designed to measure FGFR4 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.

Renin Assay Kit

80211 96 rxns.
EUR 450
Description: The Renin Assay Kit is designed to_x000D_measure Renin activity for screening and profiling applications. It comes in a convenient_x000D_96-well format, with purified, activated renin, renin substrate, and assay buffer for 100_x000D_enzyme reactions. Aliskiren Hydrochloride is also included as a control for renin_x000D_inhibition. The key to the Renin Assay Kit is the specific, fluorogenic substrate. Using this_x000D_kit, only one simple step on a microtiter plate is required for renin reactions. The_x000D_fluorometric substrate is incubated with a sample containing renin enzyme to produce a_x000D_fluorophore that can then be measured using a fluorescence reader.

HDAC3 Assay Kit

55R-1377 100 assays
EUR 527
Description: Assay Kit for detection of HDAC3 in the research laboratory

HDAC8 Assay Kit

55R-1379 100 assays
EUR 540
Description: Assay Kit for detection of HDAC8 in the research laboratory

EPHA2 Assay Kit

78002 96 rxns.
EUR 535
Description: The EPHA2 Assay Kit is designed to measure EPHA2 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. 

SPHK1 Assay Kit

78026 96 rxns.
EUR 535
Description: The SPHK1 Assay Kit is designed to measure SPHK1 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. 

HSP70 Assay Kit

78414 96 rxns.
EUR 450
Description: The HSP70 Assay Kit is a chemiluminescence assay kit designed to measure HSP70 adenosine triphosphate (ATP) hydrolysis activity for screening and profiling applications using ADP-Glo® Assay as a detection reagent.

PDE6C Assay Kit

79501 96 rxns.
EUR 405
Description: The PDE6C Assay Kit is designed for identification of PDE6C inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE6C to the binding agent.Phosphodiesterases catalyze the hydrolysis of the phosphodiester bond in dye-labeled cyclic monophosphates. Beads selectively bind the phosphate group in the nucleotide product. This increases the size of the nucleotide relative to unreacted cyclic monophosphate. In the polarization assay, dye molecules with absorption transition vectors parallel to the linearly-polarized excitation light are selectively excited. Dyes attached to the rapidly-rotating cyclic monophosphates will obtain random orientations and emit light with low polarization. Dyes attached to the slowly-rotating nucleotide-bead complexes will not have time to reorient and therefore will emit highly polarized light._x000D_The PDE6C inhibitor screening assay kit comes in a convenient 96-well format, with purified PDE6C enzyme, fluorescently labeled PDE6 substrate (cGMP), binding agent, and PDE assay buffer for 100 enzyme reactions. The key to the PDE6C Assay Kit is the specific binding agent. Using this kit, only two simple steps on a microtiter plate are required for PDE6C reactions. First, the fluorescently labeled cGMP is incubated with PDE6C for 1 hour. Second, the binding agent is added to the reaction mix to produce a change in fluorescent polarization that can then be measured using a fluorescence reader equipped for the measurement of fluorescence polarization._x000D_

BACE1 Assay Kit

71656 96 rxns.
EUR 530
Description: Bace1 (β-secretase 1) is an aspartic protease that is involved in the processing of the Amyloid precursor protein (APP). Cleavage of APP by BACE1 followed by γ-secretase results in β-amyloid peptide production, which ultimately leads toxic Aβ accumulation. In Alzheimer's disease (AD), it has been widely accepted that Aβ aggregation plays a critical role in AD pathogenesis, suggesting that BACE1 could be a potential target to treat AD. The BACE1 FRET Assay Kit is designed to measure BACE1 activity for screening and profiling applications based on fluorescence resonance energy transfer (FRET) using a labeled peptide substrate (below).

PDE1B Assay Kit

GWB-A6FB4F 96reactions Ask for price

PDE3A Assay Kit

GWB-B391E0 96reactions Ask for price

PDE7A Assay Kit

GWB-PS0CBC 96reactions Ask for price

Renin Assay Kit

GWB-PS0DBB 100reactions Ask for price

PDE5A Assay Kit

GWB-PS22C9 96reactions Ask for price

Sirt3 Assay Kit

GWB-PS340F 32rxns Ask for price

PDE1C Assay Kit

GWB-PS7A7F 96reactions Ask for price

PDE7B Assay Kit

GWB-PSB279 96reactions Ask for price

We found that t / q-IgA have significantly higher capacity to reduce plaque size of IAVs of m-IgG and IgA, most likely caused by a decrease in the number of offspring produced virus particles from infected cells. Interestingly, HA-M2 colocalization was greatly reduced on the surface of infected cells with antibodies ch-rM2ss23. These results indicate that the polymeric IgA anti-M2 Limit beginner IAV more efficient than IgG and suggested the role of anti-M2 IgA cross-protective immunity IAVs.